Increased interstitial loading reduces the effect of microstructural variations in cardiac tissue.

American Journal of Physiology. Heart and Circulatory Physiology
Marjorie Letitia Hubbard, Craig Henriquez

Abstract

Electrical propagation in diseased and aging hearts is strongly influenced by structural changes that occur in both the intracellular and interstitial spaces of cardiac tissue; however, very few studies have investigated how interactions between the two spaces affect propagation at the microscale. In this study, we used one-dimensional microstructural computer models of interconnected ventricular myocytes to systematically investigate how increasing the effective interstitial resistivity (rho(oeff)) influences action potential propagation in fibers with variations in intracellular properties such as cell coupling and cell length. Changes in rho(oeff) were incorporated into a monodomain model using a correction to the intracellular properties that was based on bidomain simulations. The results showed that increasing rho(oeff) in poorly coupled one-dimensional fibers alters the distribution of electrical load at the microscale and causes propagation to become more continuous. In the poorly coupled fiber, this continuous state is characterized by decreased gap junction delay, sustained conduction velocity, increased sodium current, reduced maximum upstroke velocity, and increased safety factor. Long, poorly coupled cells experienc...Continue Reading

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Citations

Nov 1, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Marjorie Letitia Hubbard, Craig S Henriquez
Jun 1, 2019·PLoS Computational Biology·Karoline Horgmo JægerAslak Tveito
Mar 13, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Marjorie Letitia Hubbard, Craig S Henriquez

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