Increased intestinal permeability in rats subjected to traumatic frontal lobe percussion brain injury

The Journal of Trauma
Linda FeigheryDavid J Brayden

Abstract

Dysfunction of the gastrointestinal tract is a common occurrence after traumatic brain injury (TBI). We hypothesized that increased intestinal permeability may result from a precisely controlled percussion injury to the exposed brains of anesthetized rats and that such an effect could be assessed in vitro using excised intestinal mucosae mounted in Ussing chambers. After craniotomy over the left medial prefrontal cortex on anesthetized rats, neurotrauma was produced using a pneumatically driven impactor on the exposed brain. Control rats were subjected to identical procedures but did not receive an impact. Muscle-stripped rat intestinal ileal and colonic segments were mounted in Ussing chambers within 30 minutes of death. Transepithelial electrical resistance (TEER) and the apparent permeability coefficient (Papp) of [C]-mannitol were recorded from intestinal tissue for 120 minutes. Histopathologic analysis was also performed to determine any gross morphologic changes in the intestine. Ileal and colonic mucosae showed no differences in TEER in ileum or colon of TBI rats compared with controls. The Papp of mannitol was significantly increased in ilea from rats previously exposed to TBI compared with controls. Histologic analysis...Continue Reading

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Citations

Apr 7, 2009·Journal of Neurotrauma·Vishal BansalRaul Coimbra
Nov 26, 2009·Journal of Neurotrauma·Christine CharrueauChristophe Moinard
Sep 23, 2010·Journal of Neurotrauma·Vishal BansalRaul Coimbra
Mar 6, 2010·World Journal of Gastroenterology : WJG·Katri PeuhkuriRiitta Korpela
Aug 21, 2015·Fly·Rebeccah J KatzenbergerDavid A Wassarman
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Dec 2, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H LiJ Liu
Jul 13, 2017·The Journal of Trauma and Acute Care Surgery·Lisa WrbaMarkus Huber-Lang
Mar 17, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Julien Colombani, Ditte S Andersen
Feb 26, 2020·International Journal of Molecular Sciences·John P GleesonRobert J Barrett
Feb 17, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Pengfei PanXiangyou Yu
Dec 3, 2020·Current Protocols in Mouse Biology·Jessica L Weaver
Jun 1, 2021·Journal of Neuroimmunology·Nazanin SabetMohammad Khaksari

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