PMID: 7536436Nov 1, 1994Paper

Increased intracellular glycerophosphoinositol and arachidonic acid are biochemical markers for lindane toxicity

Cellular Signalling
S SenarM A Pérez-Albarsanz

Abstract

Lindane stimulates the release of both glycerophosphoinositol and arachidonic acid from phospholipids in rat renal proximal tubular cell cultures. When lindane was added to the culture medium, a correlation between the time-course profiles of glycerophosphoinositol and arachidonate release was found. This suggests a pathway in which phosphatidylinositol is not directly broken down by phospholipase C, but can instead be broken down to glycerophosphoinositol and arachidonic acid by phospholipase A enzymes. Therefore, a mechanism of action of lindane is through its effect on glycerophosphoinositol and arachidonic acid metabolism.

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