Increased intraepithelial T-cells in stable COPD

Respiratory Medicine
Magnus J LöfdahlC Magnus Sköld

Abstract

The airway epithelium is the first line of defence in the response to inhaled particles and irritants. Chronic obstructive pulmonary disease (COPD) is an inflammatory disease characterised by an irreversible loss of lung function, with cigarette smoking as a major risk factor. Here, we address intraepithelial T-cells in COPD, as these cells are a distinct T-cell subtype thought to have important regulatory functions. We hypothesised that intraepithelial T-cells play a role in the response to lung irritants and that the T-cell populations would be altered and associated with signs of inflammation in COPD. Bronchoscopy with endobronchial mucosal biopsy sampling was performed in 22 patients (mean age; 57) with stable COPD (median FEV(1)% predicted: 51). Age- and smoking- matched smokers (S) with normal lung function (n=14) and age-matched non-smokers (NS) (n=15) served as controls. Airway inflammation was recorded visually using bronchitis index (BI). Biopsy specimens were processed into glycol methacrylate resin and inflammatory cells were stained immunohistochemically. The number of intraepithelial CD4+ T-cells were significantly higher in COPD patients compared to smokers as well as trend towards significance in non-smokers (p=...Continue Reading

References

Sep 1, 1989·The American Review of Respiratory Disease·M FournierR Pariente
Sep 1, 1993·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·K M BrittenW R Roche
Feb 1, 1993·The American Review of Respiratory Disease·M SaettaL M Fabbri
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·A BlombergT Sandström
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·M SaettaL M Fabbri
Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·A Di StefanoM Saetta
Apr 4, 2000·American Journal of Respiratory Cell and Molecular Biology·E GotoM Ando
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Di StefanoC F Donner
Aug 14, 2001·American Journal of Respiratory and Critical Care Medicine·I RetamalesJ C Hogg
Oct 6, 2001·American Journal of Respiratory Cell and Molecular Biology·T FujiiS F Van Eeden
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Marina SaettaLeonardo M Fabbri
Oct 3, 2002·The European Respiratory Journal·A Di StefanoI M Adcock
Jun 29, 2004·The European Respiratory Journal·B R CelliUNKNOWN ATS/ERS Task Force
Aug 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Di StefanoC F Donner
Apr 20, 2005·American Journal of Respiratory Cell and Molecular Biology·Steven D Shapiro, Edward P Ingenito
May 3, 2005·The European Respiratory Journal·E Roos-EngstrandA Blomberg
Nov 4, 2005·Proceedings of the American Thoracic Society·William MacNee

❮ Previous
Next ❯

Citations

Jun 24, 2009·Respiratory Research·Richard A UrbanowiczLucy C Fairclough
Jun 4, 2010·The Clinical Respiratory Journal·C Magnus Sköld
Nov 30, 2012·Clinical Science·Bethan L Barker, Christopher E Brightling
Apr 16, 2014·Biochemical and Biophysical Research Communications·Chuan QiuMingcai Li
Jul 30, 2009·Therapeutic Advances in Respiratory Disease·David A NganDon D Sin
Nov 12, 2009·Current Opinion in Pulmonary Medicine·Katarzyna GórskaRafał Krenke
Jul 27, 2017·Expert Review of Respiratory Medicine·Mathew Suji EapenSukhwinder Singh Sohal
Jun 6, 2013·Expert Review of Respiratory Medicine·Sukhwinder Singh SohalEugene Haydn Walters
Oct 11, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Maya WilliamsLucy C Fairclough
Jan 30, 2010·Current Opinion in Pulmonary Medicine

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.