Increased intrapancreatic trypsinogen activation in ischemia-induced experimental pancreatitis

Annals of Surgery
K MithöferA L Warshaw

Abstract

The potential of pancreatic ischemia to cause acute pancreatitis as indicated by morphologic changes and ectopic trypsinogen activation was investigated. Experimental evidence has shown that pancreatic ischemia is important in the evolution of severe pancreatitis, but whether ischemia can initiate pancreatitis has been disputed. Pancreatic ischemia was induced in rats by hemorrhagic hypotension (30 mm Hg for 30 min; n = 64). Changes of pancreatic microcirculatory perfusion were studied using diffuse reflectance spectroscopy. Serum amylase, trypsinogen activation peptide (TAP) in serum and pancreatic tissue, wet/dry weight ratio, and histology were determined over 24 hours and compared with sham-operated control subjects (n = 35). In control animals, serum amylase (47.9 +/- 2.1 units/L), serum (7.9 +/- 0.7 nmol/L) and tissue TAP (63.0 +/- 5.4 nmol/L x g), wet/dry weight ratio (2.8 +/- 0.1), and histology remained unchanged. Temporary hypotension markedly decreased pancreatic perfusion with incomplete recovery after reperfusion. Pancreatic isoamylase activity increased within 1 hour (110 +/- 5 units/L, p < 0.05) and further to 151 +/- 18 units/L at 24 hours. Tissue TAP was elevated at 1 hour (134 +/- 16 nmol/L x g, p < 0.05) and ...Continue Reading

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Citations

May 1, 1996·Digestive Diseases and Sciences·A L Warshaw
Aug 21, 2003·Burns : Journal of the International Society for Burn Injuries·Michael D WilsonPeter Dziewulski
Aug 1, 1995·Annals of Surgery·C M RyanR G Tompkins
Oct 20, 2000·Pancreas·W HartwigE Klar
Oct 5, 2007·Journal of Gastroenterology and Hepatology·Christopher ChristophiCaterina Malcontenti-Wilson
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·T KeckS González
May 16, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jens WernerMarkus W Büchler
Jun 24, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Brigitte Vollmar, Michael D Menger
Sep 24, 1999·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E AlhanS Al
Oct 29, 2010·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·J GrauvogelJ Werner
Sep 21, 2010·Burns : Journal of the International Society for Burn Injuries·Haidy G RiveroMarc G Jeschke
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May 12, 1998·The American Journal of Physiology·S W SchmidF S Gorelick
Nov 17, 1998·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·G H SakorafasM G Sarr

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