Increased Intrinsic Activity of Medial-Temporal Lobe Subregions is Associated with Decreased Cortical Thickness of Medial-Parietal Areas in Patients with Alzheimer's Disease Dementia

Journal of Alzheimer's Disease : JAD
Lorenzo PasquiniChristian Sorg

Abstract

In Alzheimer's disease (AD), disrupted connectivity between medial-parietal cortices and medial-temporal lobes (MTL) is linked with increased MTL local functional connectivity, and parietal atrophy is associated with increased MTL memory activation. We hypothesized that intrinsic activity in MTL subregions is increased and associated with medial-parietal degeneration and impaired memory in AD. To test this hypothesis, resting-state-functional and structural-MRI was assessed in 22 healthy controls, 22 mild cognitive impairment patients, and 21 AD-dementia patients. Intrinsic activity was measured by power-spectrum density of blood-oxygenation-level-dependent signal, medial-parietal degeneration by cortical thinning. In AD-dementia patients, intrinsic activity was increased for several right MTL subregions. Raised intrinsic activity in dentate gyrus and cornu ammonis 1 was associated with cortical thinning in posterior cingulate cortices, and at-trend with impaired delayed recall. Critically, increased intrinsic activity in the right entorhinal cortex was associated with ipsilateral posterior cingulate degeneration. Our results provide evidence that in AD, intrinsic activity in MTL subregions is increased and associated with medi...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Nov 5, 2003·Nature Reviews. Neuroscience·Mark D'EspositoAdam Gazzaley
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Nov 4, 2005·Cerebral Cortex·E LudersA W Toga
Apr 25, 2006·Lancet·Serge GauthierUNKNOWN International Psychogeriatric Association Expert Conference on mild cognitive impairment
Jun 20, 2006·Lancet·Peter Whitehouse, Henry Brodaty
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Jun 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas VillainGaël Chételat
Feb 11, 2009·Archives of Neurology·Jorge J Palop, Lennart Mucke
Jan 14, 2010·Neuromolecular Medicine·Reisa A SperlingKeith A Johnson
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sanna MalinenRiitta Hari
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael A YassaCraig E L Stark
Apr 15, 2011·Brain : a Journal of Neurology·Alexander DrzezgaReisa A Sperling
Jul 12, 2011·Neuroscience and Biobehavioral Reviews·Heidi I L JacobsHarry B M Uylings
Jul 30, 2011·Journal of Alzheimer's Disease : JAD·Chuanming LiHanjian Du
Aug 4, 2011·NeuroImage·Koene R A Van DijkRandy L Buckner
Aug 13, 2011·AJNR. American Journal of Neuroradiology·B J HanseeuwA Ivanoiu
Dec 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deepti PutchaReisa Sperling
May 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Marc Aurel BuscheArthur Konnerth
Jul 13, 2012·The New England Journal of Medicine·Randall J BatemanUNKNOWN Dominantly Inherited Alzheimer Network
Sep 21, 2012·Nature Reviews. Neuroscience·Charan Ranganath, Maureen Ritchey
Jan 29, 2013·Nature Neuroscience·György Buzsáki, Edvard I Moser
Jun 4, 2013·Behavioural Brain Research·Jiuquan ZhangJian Wang
Jul 6, 2013·NeuroImage·Dongming ZhouChristian Beaulieu
Aug 2, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah L DeVosTimothy M Miller
Mar 13, 2014·Journal of Internal Medicine·R C PetersenL Fratiglioni
Apr 8, 2014·Neurology·Clifford R JackRonald C Petersen

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Citations

Nov 2, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Ji Eun ParkUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Apr 30, 2019·Human Brain Mapping·Long XieUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 20, 2021·Annals of Neurology·Sophie DautricourtGaël Chételat

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