Increased L1CAM (CD171) levels are associated with glioblastoma and metastatic brain tumors

Medicine
Robin WachowiakUlf Nestler

Abstract

L1 cell adhesion molecule (L1CAM) is a member of the immunoglobulin-like cell-adhesion molecule family that was shown to be associated with a worse prognosis in several human cancers. L1 ectodomain shedding via vesicles or exosomes has been detected in extracellular fluids after cleavage from the cell surface by metalloproteases. We evaluated the presence of L1CAM in cyst fluid and tissue from glioblastomas or brain metastases.The amount of L1CAM in cyst fluid of 9 glioblastomas and 11 brain metastases was assessed using enzyme-linked immunosorbent assay (ELISA). Corresponding tumor tissue slices were stained immunohistochemically for L1CAM. Cerebrospinal fluid of 20 non-tumor patients served as controls.Mean levels of L1CAM in tumor cyst fluid were significantly higher in glioblastoma (6118 ± 4095 ng/mL) and metastasis patients (8001 ± 6535 ng/mL) than in CSF of control patients (714 ± 22 ng/mL). The immunohistochemical expression of L1CAM in corresponding tissue was significantly higher in metastases than in glioblastomas.The present study demonstrates high levels of L1CAM in cyst fluid of glioblastoma and metastatic brain tumors. Soluble L1CAM may represent a motility promoting molecule in cancer progression, a co-factor for...Continue Reading

References

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Citations

Nov 17, 2019·International Journal of Molecular Sciences·Heng Liang Tan, Andre Choo
Nov 23, 2019·British Journal of Cancer·Takashi IchikawaMasato Kusunoki
May 21, 2020·Journal of Clinical Medicine·Marco Giordano, Ugo Cavallaro
Nov 8, 2019·Cancer Biotherapy & Radiopharmaceuticals·Qing-Jun LiuLei-Bo Wang

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

JMP
Prism

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