Abstract
Laminin is a basement membrane (BM) glycoprotein composed of three of five subunits, the A, M, B1, B2, and the S chain. Four forms of laminin, A-B1-B2, A-S-B2, M-B1-B2, and M-S-B2, have been identified. Laminin is implicated in various biological processes such as cell adhesion and differentiation. We studied immunohistochemically the expression of the four laminin subunits A, M, B1, B2 as well as of neural cell adhesion molecule (N-CAM, CD56), a marker of regenerating myofibers, in various neuromuscular disorders. In normal muscle, the predominant subunits of myofiber laminin were M, B1, and B2. The A chain was only faintly expressed in myofiber BM. In inflammatory myopathies and dystrophinopathies myofiber laminin A expression was greatly increased. An average of 80% and 63% of laminin A-positive myofibers in inflammatory myopathies and dystrophinopathies, respectively, were additionally CD56 positive. Laminin A and CD56 expression in denervating diseases and mitochondrial myopathies were negligible. Expression of M, B1, and B2 subunits did not seem to be altered in the diseased conditions examined above. The data suggest that laminin A is upregulated in inflammatory myopathies and dystrophinopathies and, most markedly in reg...Continue Reading
References
Dec 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D R Abrahamson, P L St John
Apr 1, 1992·Muscle & Nerve·T Hurme, H Kalimo
Jan 1, 1992·Experimental Cell Research·E EngvallM Paulsson
Feb 20, 1992·Nature·O Ibraghimov-BeskrovnayaK P Campbell
Jan 1, 1991·Neuromuscular Disorders : NMD·H S AlameddineM Fardeau
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K EhrigE Engvall
Jan 1, 1990·Annals of the New York Academy of Sciences·K EhrigE Engvall
Oct 1, 1990·The Journal of Cell Biology·J R SanesD D Hunter
Jan 26, 1990·Cell·M EkblomP Ekblom
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W SchubertA Starzinski-Powitz
Mar 16, 1989·Nature·D D HunterJ R Sanes
Oct 21, 1988·Cell·G KleinP Ekblom
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I Leivo, E Engvall
Jan 1, 1988·Developmental Biology·M OcalanK von der Mark
Oct 1, 1983·The Journal of Cell Biology·A K GulatiA A Zalewski
Jun 1, 1984·Developmental Biology·A Y Chiu, J R Sanes
Jul 25, 1981·Journal of Molecular Biology·J EngelR Timpl
Aug 1, 1983·Developmental Biology·C C Howe, B Dietzschold
Oct 1, 1982·Developmental Biology·U KühlK von der Mark
Sep 1, 1981·European Journal of Biochemistry·A R CooperB L Hogan
Feb 1, 1994·Journal of Neurology·S BeyenburgF Jerusalem
Oct 1, 1993·Journal of the Neurological Sciences·Y K HayashiK Arahata
Jan 1, 1993·Kidney International·E Engvall
Citations
Dec 9, 1997·Muscle & Nerve·C F Tiger, D Gullberg
Sep 29, 2004·Histochemistry and Cell Biology·Maria Cristina SalimenaThereza Quírico-Santos
Dec 1, 1996·Matrix Biology : Journal of the International Society for Matrix Biology·M DurbeejM Ekblom
Dec 23, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·M FalkP Ekblom
Oct 1, 1996·Current Opinion in Cell Biology·P Ekblom
Nov 2, 1999·Neuromuscular Disorders : NMD·B L PattonJ R Sanes
Jan 26, 1999·Annals of the New York Academy of Sciences·M EkblomP Ekblom
Jun 10, 1998·Nucleic Acids Research·N KholodL Kisselev
May 23, 2012·Bioinformatics·David Hoksza, Daniel Svozil
Feb 12, 1998·The Journal of Cell Biology·B L PattonJ R Sanes
Oct 6, 1997·The Journal of Cell Biology·J E SugiyamaZ W Hall
Jan 4, 2012·Journal of Cutaneous Pathology·Kristopher McKayAntonio Subtil
Dec 21, 2006·Differentiation; Research in Biological Diversity·Ricarda NeuBarbara Munz
Oct 31, 2000·Microscopy Research and Technique·B L Patton
Nov 14, 1997·The Journal of Biological Chemistry·C F TigerD Gullberg