Increased latencies to initiate cocaine self-administration following laterodorsal tegmental nucleus lesions

Behavioural Brain Research
Stephan SteidlRoy A Wise

Abstract

Cholinergic input to the ventral tegmental area (VTA), origin of the mesocorticolimbic dopamine system that is critical for cocaine reward, is important for both cocaine seeking and cocaine taking. The laterodorsal tegmental nucleus (LDTg) provides one of the two major sources of excitatory cholinergic input to the VTA, but little is known of the role of the LDTg in cocaine reward. LDTg cholinergic cells express urotensin-II receptors and here we used local microinjections of a conjugate of the endogenous ligand for these receptors with diphtheria toxin (Dtx::UII) to lesion the cholinergic cells of the LDTg in rats previously trained to self-administer cocaine (1mg/kg/infusion, i.v.). Lesioned rats showed long latencies to initiate cocaine self-administration after treatment with the toxin, which resulted in a reduction in cocaine intake per session. Priming injections reduced latencies to initiate responding for cocaine in lesioned rats, and once they began to respond the rats regulated their moment-to-moment cocaine intake within normal limits. Thus we conclude that while LDTg cholinergic cell loss does not significantly alter the rewarding effects of cocaine, LDTg lesions can reduce the rat's responsiveness to cocaine-predic...Continue Reading

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Feb 27, 2014·Behavioural Brain Research·Lauren K Dobbs, Christopher L Cunningham

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Citations

Mar 26, 2016·Frontiers in Psychiatry·Idaira Oliva, Matthew J Wanat
Sep 19, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David J ReinerMatthew R Hayes
Jun 10, 2017·Pharmacology Research & Perspectives·Mads Ødum LambertKristi Anne Kohlmeier
Feb 14, 2021·Neuroscience and Biobehavioral Reviews·Ewa Galaj, Robert Ranaldi
Oct 10, 2021·Alcoholism, Clinical and Experimental Research·Chandrika Abburi, John McDaid

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