PMID: 9529118Apr 7, 1998Paper

Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha

Infection and Immunity
A MoshyediL L Moldawer

Abstract

Plasma leptin and ob gene mRNA levels were increased in mice following bacterial peritonitis, and blocking an endogenous tumor necrosis factor alpha (TNF-alpha) response blunted the increase. However, plasma leptin concentrations did not correlate with the associated anorexia. We conclude that leptin expression is under partial regulatory control of TNF-alpha in peritonitis, but the anorexia is not dependent on increased leptin production.

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