PMID: 6161367Nov 1, 1980Paper

Increased levels of (2'-5')oligo(A) polymerase activity in human lymphoblastoid cells treated with glucocorticoids

Proceedings of the National Academy of Sciences of the United States of America
I Krishnan, C Baglioni

Abstract

An enzymatic activity that synthesizes (2'-5')-oligo(A) from ATP is induced in animal cells treated with interferon. This activity, designated (2'-5')A polymerase, is also elevated in human lymphoblastoid Daudi and Raji cells treated with hydrocortisone. The polymerase activity increases significantly after 24 hr of treatment and declines when hydrocortisone is removed from the culture medium. The product of the enzyme prepared from hydrocortisone-treated cells is indistinguishable from (2'-5')oligo(A) synthesized with polymerase of interferon-treated cells either by an endonuclease activation assay or by chromatographic analysis. The increase in (2'-5')A polymerase is not mediated by secretion of interferon by hydrocortisone-treated cells; less than 1 unit of interferon per ml is present in the culture medium during treatment with this glucocorticoid hormone. Moreover, this increase is related to the concentration of hydrocortisone in the culture medium and is inhibited by the addition of cortexolone. This steroid interferes with the interaction between glucocorticoid hormones and their receptor. Cortexolone has no effect, however, on the induction of (2'-5')A polymerase by interferon. The synthetic glucocorticoid dexamethason...Continue Reading

References

Aug 1, 1975·The Journal of General Virology·A AdamsK Cantell
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A KimchiM Revel
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·I M Kerr, R E Brown
Oct 27, 1978·Biochimica Et Biophysica Acta·I Gresser, M G Tovey
Nov 1, 1979·European Journal of Biochemistry·D K West, C Baglioni
Aug 24, 1972·The New England Journal of Medicine·H N Claman
Jan 24, 1980·Nature·J E Blalock, J D Stanton

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Citations

May 1, 1984·Somatic Cell and Molecular Genetics·L M ShulmanF H Ruddle
Nov 30, 1983·Biochemical and Biophysical Research Communications·J M WuA R Semproni
Jan 1, 1984·Pharmacology & Therapeutics·G C Sen
Apr 22, 1985·Biochimica Et Biophysica Acta·M F HeilJ W Chiao
Feb 14, 1984·Biochimica Et Biophysica Acta·A R Semproni, J M Wu
Jun 12, 1998·Pharmacology & Therapeutics·M R Player, P F Torrence
Jun 5, 1999·Journal of Internal Medicine·A Vojdani
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P W DoetschE E Henderson
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H CaillaJ Marti
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M Etienne-SmekensJ E Dumont
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G MerlinM Revel
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L LaurenceH Cailla
Jan 1, 1987·Journal of Toxicology and Environmental Health·D K Liu, G F Owens
Apr 15, 1983·European Journal of Biochemistry·M C HaughI M Kerr
May 1, 1989·Biological Reviews of the Cambridge Philosophical Society·T Alderson
Dec 1, 1995·Canadian Journal of Physiology and Pharmacology·E DelaporteK W Renton
Dec 29, 2011·Frontiers in Bioscience (Scholar Edition)·Heather J Ezelle, Bret A Hassel
Apr 14, 1982·Biochemical and Biophysical Research Communications·J Oikarinen
Jul 30, 1982·Biochemical and Biophysical Research Communications·T LeandersonE Lundgren
Jun 29, 1984·Biochemical and Biophysical Research Communications·D K Liu, G F Owens
Mar 15, 1991·Biochemical and Biophysical Research Communications·N F Rebbe, S Hickman
Nov 16, 1981·Biochemical and Biophysical Research Communications·F BesançonM N Thang
May 12, 2004·Journal of Cellular Physiology·Enrico GalmozziSylvie Ménard
May 1, 1987·Journal of Virology·W G Hearl, M I Johnston
May 1, 1983·Molecular and Cellular Biology·A A CreaseyT C Merigan
Jan 1, 1982·Differentiation; Research in Biological Diversity·J MartiJ Lafont

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