Increased levels of 8-hydroxy-2'-deoxyguanosine are attributable to organophosphate pesticide exposure among young children

Environmental Pollution
Guodong DingYing Tian

Abstract

Oxidative damage has been proposed as an important mechanism linking pesticide exposure to health effects. A study of 268 young Shanghai children was conducted to examine the relationship between organophosphate pesticide (OP) exposure and a biomarker of oxidative DNA damage. Urine samples were analyzed for five nonspecific dialkyl phosphate (DAP) metabolites [dimethyl phosphates (DMs) and diethyl phosphates (DEs)] and 8-hydroxy-2'-deoxyguanosine (8-OHdG). The creatinine-adjusted median of 8-OHdG in urine samples was 3.99 ng/mg. Increased exposure to OPs was associated with greater levels of urinary 8-OHdG [total DAPs: ß (adjusted)=0.46 per log(10) unit increase, 95% confidence interval (CI)=0.40-0.53, p=0.000; DMs: ß (adjusted)=0.34, 95% CI=0.28-0.41, p=0.000; DEs: ß (adjusted)=0.48, 95% CI=0.42-0.54, p=0.000]. Thus, the 8-OHdG biomarker is useful for increasing our understanding of the link between childhood exposure to OPs and health outcomes.

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Citations

Sep 10, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hiroyuki KataokaAkihiro Saito
Aug 5, 2014·The Science of the Total Environment·Michalis KoureasChristos Hadjichristodoulou
Feb 27, 2020·Current Topics in Medicinal Chemistry·Ana Laura García SoriaEsvieta Tenorio-Borroto
Mar 23, 2019·Environmental Science and Pollution Research International·Ratana SapbamrerBoonsita Suwannakul
May 2, 2020·Environmental Science and Pollution Research International·Ratana SapbamrerSupakit Khacha-Ananda

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