Abstract
Cysteine proteases [cathepsin B (CATB), cathepsin L (CATL)], the serine protease urokinase-type plasminogen activator (UPA) and its inhibitor type-1 (PAI-1) play an important part in cancer invasion. No data are available on the relationship between these proteases and gastric precancerous changes. To determine CATB, CATL, UPA, PAI-1 in chronic atrophic gastritis, intestinal metaplasia and gastric epithelial dysplasia, as precancerous changes, and to compare these data with those obtained in gastric cancer. Endoscopic biopsies were obtained from 12 patients with gastric cancer (cancerous tissue), 33 patients with chronic atrophic gastritis (all with intestinal metaplasia and 12 with dysplasia) and from 47 control subjects, for a total of 92 patients. Antigen concentrations were measured using ELISA methods. Immunohistochemistry was performed using monoclonal anti-CATB and anti-PAI-1 antibodies. CATB, CATL, UPA and PAI-1 were significantly higher in chronic atrophic gastritis than in controls (CATB: P < 0.001; CATL: P < 0.005; UPA: P < 0.000001; PAI-1: P < 0.005). The same was observed for cancer. CATB and UPA were significantly higher in chronic atrophic gastritis, with versus without dysplasia (P < 0.05). Dysplastic epithelia ...Continue Reading
Citations
Oct 3, 1999·Cancer·L HerszènyiF Farinati
Mar 19, 2008·Pathology Oncology Research : POR·László HerszényiZsolt Tulassay
Mar 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Izabela Berdowska
Feb 17, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·L HerszényiF Farinati
Feb 9, 2002·Urology·Andrea StaackKlaus Jung
Apr 22, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B FriedrichS A Loening
Aug 9, 2003·Oral Oncology·Maricris Macabeo-OngRichard C K Jordan
Jun 10, 2000·Histopathology·R HildenbrandM Schmitt
Jan 5, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kristin G NørsettAndrea Varro
Jul 5, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Susan KennyAndrea Varro
Jul 12, 2008·BMC Cancer·László HerszényiZsolt Tulassay
Mar 2, 2013·PloS One·Maki Konno-ShimizuKazuhiko Koike
Jun 16, 2004·Biological Chemistry·Frank BühlingThomas Wex
Aug 21, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·László HerszényiFabio Farinati
May 9, 2012·Cancer Genetics·Song-Nan ZhangXiong-Hu Shen
Jul 19, 2005·The Journal of Pathology·Sabine KruegerAlbert Roessner
Dec 18, 2003·Journal of Experimental Therapeutics & Oncology·Yousif SalehJacek Rybka
Jan 21, 2006·Helicobacter·Thomas WexPeter Malfertheiner
Apr 4, 2016·Peptides·Reidar FossmarkKristin G Nørsett
Aug 25, 2015·Pharmacology & Therapeutics·Dhivya R Sudhan, Dietmar W Siemann
Nov 4, 2006·Analytical Biochemistry·Hyun Gyung JangGerald N Wogan
Jan 14, 2011·The Journal of International Medical Research·J-A YanW-B Li
Nov 20, 1997·The Journal of Biological Chemistry·C A Iacobuzio-DonahueM J Murnane
Mar 25, 2005·Proteomics·Matthias P A EbertChristoph Röcken
Oct 14, 2014·World Journal of Gastroenterology : WJG·László HerszényiZsolt Tulassay
Nov 1, 2002·The International Journal of Biological Markers·L SanzJ L García-Muñíz
Sep 13, 2020·Cell Biochemistry and Biophysics·Chun-Hua WangFu-Ming Tsai
Dec 18, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Surinder M Soond, Andrey A Zamyatnin