Increased levels of conditioned fear and avoidance behavior coincide with changes in phosphorylation of the protein kinase B (AKT) within the amygdala in a mouse model of extremes in trait anxiety

Neurobiology of Learning and Memory
Yi-Chun YenC T Wotjak

Abstract

Patients diagnosed for anxiety disorders often display faster acquisition and slower extinction of learned fear. To gain further insights into the mechanisms underlying these phenomenona, we studied conditioned fear in mice originating form a bi-directional selective breeding approach, which is based on elevated plus-maze behavior and results in CD1-derived high (HAB), normal (NAB), and low (LAB) anxiety-related behavior mice. HAB mice displayed pronounced cued-conditioned fear compared to NAB/CD1 and LAB mice that coincided with increased phosphorylation of the protein kinase B (AKT) in the basolateral amygdala 45 min after conditioning. No similar changes were observed after non-associative immediate shock presentations. Fear extinction of recent but not older fear memories was preserved. However, HAB mice were more prone to relapse of conditioned fear with the passage of time. HAB mice also displayed higher levels of contextual fear compared to NAB and LAB mice and exaggerated avoidance following step-down avoidance training. Interestingly, HAB mice showed lower and LAB mice higher levels of acoustic startle responses compared to NAB controls. The increase in arousal observed in LAB mice coincided with the general absence of...Continue Reading

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Citations

Mar 19, 2014·BMC Genomics·Man Chun John MaAnne E Kwitek
Feb 25, 2014·Psychopharmacology·Rolf T HansenHan-Ting Zhang
Mar 24, 2016·Psychopharmacology·Luke AyersJeffrey B Rosen
Jun 18, 2014·Radiation Research·Tara Beth SweetM Kerry O'Banion
Jan 31, 2017·Neurobiology of Learning and Memory·Amanda S Russo, Ryan G Parsons
Nov 1, 2018·Psychopharmacology·Nicolas Singewald, Andrew Holmes
May 28, 2020·Frontiers in Behavioral Neuroscience·Lydia Giménez-LlortJosé Ramón Bayascas
Nov 6, 2020·The International Journal of Neuropsychopharmacology·Dayan KnoxEmily Moulton
Jul 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Valentina ChiodiManlio Vinciguerra

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