Increased levels of F2-isoprostanes following aneurysmal subarachnoid hemorrhage in humans

Free Radical Biology & Medicine
Chih-Lung LinHsiu-Chuan Yen

Abstract

Subarachnoid hemorrhage (SAH) resulting from aneurysmal rupture is the major cause of nontraumatic SAH. We hypothesized that oxidative stress could be increased following aneurysmal SAH due to hemoglobin release and ischemia-reperfusion injury and that may further contribute to poor outcome. We collected plasma and cerebrospinal fluid (CSF) samples from 11 non-SAH controls and 15 aneurysmal SAH patients for up to 10 days after surgery and investigated status of oxidative stress in patients. Results showed that mean or peak levels of F(2)-isoprostanes (F(2)-IsoPs), a specific marker of lipid peroxidation, and total nitrate/nitrite, metabolites of nitric oxide and peroxynitrite, in CSF and plasma were significantly higher in SAH patients than in controls. First-day levels were also higher in CSF, but not in plasma, in SAH patients. Moreover, mean and peak levels of CSF F(2)-IsoPs were positively correlated with poor outcome or severity of clinical conditions in patients. Furthermore, levels of retinol, delta-tocopherol, beta+gamma-tocopherol, lutein, beta-carotene, and coenzyme Q(10) in plasma were significantly lower in SAH patients than in controls. Our results indicate that oxidative damage may play important roles in the seve...Continue Reading

References

Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·R L Macdonald, B K Weir
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroR E Byrns
Aug 1, 1996·Stroke; a Journal of Cerebral Circulation·C IadecolaM E Ross
Jan 27, 1998·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·S T OmayeW R Bidlack
Apr 28, 1999·Free Radical Biology & Medicine·V P PalaceP K Singal
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hartmut Jaeschke
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·Matthew J McGirtDavid S Warner
Mar 27, 2003·Current Opinion in Critical Care·Nazli Janjua, Stephan A Mayer
May 6, 2003·Biochemical and Biophysical Research Communications·Klas BlomgrenHenrik Hagberg
Feb 6, 2004·Biochimica Et Biophysica Acta·Mikael TurunenGustav Dallner
Apr 15, 2004·Free Radical Biology & Medicine·Scott CassieLee Anne Tibbles
Jun 15, 2004·Life Sciences·R Loch MacdonaldMichael Sajdak
Jul 21, 2004·Cell Calcium·Anatoly A StarkovGary Fiskum

❮ Previous
Next ❯

Citations

Nov 13, 2007·Journal of Neurology·M J de LeonD Pratico
Dec 17, 2010·Molecular Neurobiology·Fatima A SehbaJohn H Zhang
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Olivier BoutaudL Jackson Roberts
Aug 30, 2008·Antioxidants & Redox Signaling·Chandramohan WakadeKrishnan M Dhandapani
Feb 23, 2010·Antioxidants & Redox Signaling·Brandon J Reeder
Jun 28, 2011·Antioxidants & Redox Signaling·Tomas B CorcoranTrevor A Mori
Jun 19, 2012·Antioxidants & Redox Signaling·Chris E CooperAbdu I Alayash
Jan 10, 2012·Cerebrovascular Diseases·Michael MoussouttasKarel Pacak
Jan 5, 2008·Neurological Research·Axel Petzold
Mar 28, 2013·Stroke Research and Treatment·Mohammed SabriR Loch Macdonald
Apr 26, 2012·Expert Opinion on Investigational Drugs·Christine BarryRobert Vink
Mar 15, 2012·Progress in Neurobiology·Fatima A SehbaJohn H Zhang
Sep 21, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Shivanand P LadGary K Steinberg
Mar 6, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Stephen B LewisGerry Shaw
Oct 25, 2012·Journal of Neurochemistry·Basak CanerJohn H Zhang
Oct 1, 2013·Progress in Neurobiology·Sheng ChenJohn H Zhang
Feb 22, 2011·Free Radical Biology & Medicine·Frederic T BillingsMias Pretorius
May 11, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Magdalena M Przybycien-Szymanska, William W Ashley
Jan 9, 2020·Cephalalgia : an International Journal of Headache·Wei-Hsiang HsuYun-Lian Lin
Feb 13, 2019·Critical Care : the Official Journal of the Critical Care Forum·David LagierLionel J Velly
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iwona Jarocka-KarpowiczZenon Dionizy Mariak
Sep 29, 2012·Annals of Clinical Biochemistry·Zhi-Jiang Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.