Increased levels of HSPA5 in the serum of patients with inflammatory myopathies--preliminary findings

Clinical Rheumatology
Fei XiaoXue-Feng Wang

Abstract

Endoplasmic reticulum (ER) stress is suggested to play an important role in the pathogenesis of myositis recently. The aim of this study was to investigate the serum concentration of an ER stress-specific chaperone protein HSPA5 in patients with inflammatory myopathies. Forty-five patients (27 with polymyositis (PM) and 18 with dermatomyositis (DM)) were included in the study, and all received prednisone therapy. Serum samples were collected from each patient before and after prednisone treatment. Serum HSPA5 levels were detected by enzyme-linked immunosorbent assays. The serum level of HSPA5 was significantly higher in myositis patients than in controls. In addition, the concentrations in the DM subgroup were significantly higher than in the PM groups. Serum HSPA5 levels were positively correlated with creatine kinase (CK) and C-reactive protein (CRP) in PM patients. In patients with DM, the serum HSPA5 concentrations were also found significantly correlated with CK, but not with CRP. After prednisone treatment, serum HSPA5 levels significantly decreased compared to baseline in steroid responders, but no marked decrease was observed in steroid non-responders. Serum HSPA5 is increased in patients with DM and PM. Increased conce...Continue Reading

References

Feb 13, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Feb 1, 1997·Trends in Biochemical Sciences·H L Pahl, P A Baeuerle
Jul 13, 2004·Arthritis and Rheumatism·Lisa G RiderUNKNOWN International Myositis Assessment and Clinical Studies Group
Nov 13, 2008·Cytotechnology·Saeed U Khan, Martin Schröder
Jan 27, 2011·Methods in Enzymology·Heather M AlgerKanneboyina Nagaraju
Jul 12, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Wen-Chin WengHsinyu Lee
Sep 16, 2011·Exercise and Sport Sciences Reviews·Louise DeldicqueMarc Francaux
Mar 14, 2012·Current Rheumatology Reports·Sree RayavarapuKanneboyina Nagaraju
May 2, 2012·Arthritis Research & Therapy·William ColeyKanneboyina Nagaraju
Jun 12, 2013·Journal of Genetic Syndromes & Gene Therapy·Marina S Gorbatyuk, Oleg S Gorbatyuk
Jul 1, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Kihoon KimKyung-Oh Doh

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Citations

Dec 15, 2017·The FEBS Journal·Dil Afroze, Ashok Kumar
Feb 16, 2019·Journal of Immunology Research·Charles CassiusReyhan Amode

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