Increased levels of IgG subclasses specific for Pseudomonas aeruginosa exoenzyme and polysaccharide antigens in chronically infected patients with cystic fibrosis.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
A AlbusG Döring

Abstract

IgG subclass levels to Pseudomonas aeruginosa alginate, alkaline proteinase, elastase and exotoxin A in sera of healthy adults, non-infected and infected cystic fibrosis patients were investigated by enzyme linked immunosorbent assay. Whereas healthy adults and non-infected cystic fibrosis patients revealed mostly negative IgG subclass levels to the four antigens, infected cystic fibrosis patients had significantly elevated IgG1, IgG2, IgG3 and IgG4 levels to both the protein antigens as well as the polysaccharide antigen. The study does not support previous findings of an impaired natural IgG2 response to polysaccharide antigen. The study does not support previous findings of an impaired natural IgG2 response to polysaccharide in chronically infected cystic fibrosis patients.

References

Jan 1, 1986·Annual Review of Microbiology·N HøibyP O Schiøtz
Aug 1, 1988·Chest·G DöringN Høiby
Aug 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·W D BiggarR A Good
Apr 1, 1983·The Journal of Infectious Diseases·G DöringA Hofmann

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Citations

Dec 11, 2008·Journal of Gastroenterology and Hepatology·Antonio M Morselli-Labate, Raffaele Pezzilli
Oct 14, 2003·American Journal of Respiratory and Critical Care Medicine·Ronald L GibsonBonnie W Ramsey
Sep 1, 1992·International Journal of Antimicrobial Agents·N Høiby
Oct 7, 2008·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Tacjana PresslerUNKNOWN Scandinavian CF Study Consortium
Oct 9, 1999·Journal of Bacteriology·R M AndersonL Rust

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