Increased levels of irisin in people with long-standing Type 1 diabetes

Diabetic Medicine : a Journal of the British Diabetic Association
Daniel EspesPer-Ola Carlsson

Abstract

Irisin stimulates browning of white adipose tissue and improves metabolic control in mice. Betatrophin, another recently described hormone, improves metabolic control in mice by inducing β-cell proliferation. In vitro, irisin stimulates the expression of betatrophin in rat adipocytes. There is a great interest in developing drugs that target or use these hormones for the treatment of obesity and diabetes. We have previously reported on increased levels of betatrophin in people with Type 1 diabetes, but the levels of irisin are currently unknown. To characterize the levels of irisin in Type 1 diabetes and investigate a potential correlation with betatrophin. Irisin and betatrophin were measured by enzyme-linked immunosorbant assay (ELISA) in 45 individuals with Type 1 diabetes and in 25 healthy controls. Irisin levels were increased in people with Type 1 diabetes, and especially in women. Negative correlations between irisin levels and age at onset of Type 1 diabetes and plasma triacylglycerol levels were observed. Interestingly, in women with Type 1 diabetes a negative correlation between irisin and insulin doses was also observed. When computing correlations for all study participants, a positive correlation between irisin and...Continue Reading

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Citations

May 24, 2016·EBioMedicine·Hong TangWeizhen Zhang
Aug 4, 2015·Clinical Biochemistry·Iffet Dağdelen DuranSerdar Güler
Dec 24, 2015·Journal of Diabetes Research·Sheyu LiHaoming Tian
Jun 27, 2015·PloS One·Natalia Wawrusiewicz-KurylonekMaria Gorska
Jun 11, 2019·European Journal of Gastroenterology & Hepatology·Shayan ChenLin Zhao
Nov 24, 2019·International Journal of Molecular Sciences·Olof ErikssonDaniel Espes
Feb 14, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·James J McCormickGlen P Kenny
Jul 20, 2017·Diabetes/metabolism Research and Reviews·Mohamed Abu-FarhaJaakko Tuomilehto
Nov 25, 2017·Endocrine·Stergios A PolyzosChristos S Mantzoros
Aug 9, 2019·Indian Journal of Clinical Biochemistry : IJCB·Ramalingam MageswariK V Vinod
Nov 8, 2018·International Journal of Endocrinology·Ilse Yessabel Martinez MunozJose de Jesus Garduno Garcia
Jun 12, 2020·Therapeutic Advances in Endocrinology and Metabolism·Aleksandra ŻebrowskaBarbara Hall
May 24, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xin SuBin Wang
Jul 31, 2021·World Journal of Diabetes·Giacomina BrunettiMaria Felicia Faienza

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