Increased levels of plasma glial-derived neurotrophic factor in children with attention deficit hyperactivity disorder

Nordic Journal of Psychiatry
Se-Hoon ShimYong-Ku Kim

Abstract

Recent evidence suggests that neurotrophic growth factor systems, including brain-derived neurotrophic factor, might be involved in the pathophysiology of attention deficit hyperactivity disorder (ADHD). Glial cell line-derived neurotrophic factor (GDNF) is from the transforming growth factor-β family and is abundantly expressed in the central nervous system, where it plays a role in the development and function of hippocampal cells. To date, no association studies have been done between ADHD and GDNF. Thus, here we investigate the hypothesis that there are differences in plasma GDNF levels between children with ADHD and healthy controls. Plasma GDNF levels were measured in 86 drug-naïve children with ADHD and 128 healthy children. The severity of ADHD symptoms was determined by scores on the Korean ADHD Rating Scale (K-ARS) in patients and healthy controls. The median plasma GDNF levels in ADHD patients was 74.0 (IQR: 23.4-280.1) pg/ml versus 24.6 (IQR: 14.5-87.3) pg/ml in healthy controls; thus the median plasma GDNF levels in ADHD patients were significantly higher than in healthy controls (Mann-Whitney U-test, P < 0.01). Plasma GDNF levels were correlated positively with K-ARS subscale scores (inattention, hyperactivity-imp...Continue Reading

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Citations

Feb 2, 2016·Neurobiology of Disease·Carlos F Ibáñez, Jaan-Olle Andressoo
Apr 23, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Se-Hoon ShimYong-Ku Kim
Feb 6, 2017·Neuroscience and Biobehavioral Reviews·Marieke KleinBarbara Franke
Jul 30, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jungyun KimJaeku Kang
Jul 29, 2017·Frontiers in Psychiatry·Alma Y Galvez-ContrerasOscar Gonzalez-Perez
Sep 8, 2017·Frontiers in Molecular Neuroscience·Daniel CortésIván Velasco

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