Increased levels of serum granzyme-B is associated with insulin resistance and increased cardiovascular risk in adolescent polycystic ovary syndrome patients

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Efser OztasHalil Ibrahim Yakut

Abstract

Our aim was to determine serum perforin and granzyme-B levels in adolescent PCOS patients, and to investigate whether they are associated with some of the insulin sensitivity, obesity and cardiovascular (CV) risk markers and metabolic syndrome. A case-control study was carried out including a total of 172 adolescents (83 PCOS patients and 89 age-matched healthy controls). Participants were recruited consecutively. Homeostasis model assessment (HOMA-IR), lipid parameters, and anthropometric measurements were determined. Serum perforin and granzyme B levels were measured by commercially available ELISA kits. HOMA-IR>3.16 was considered to indicate the presence of insulin resistance. Logistic regression analysis was applied for the predictive value of granzyme-B for increased CV risk in PCOS patients. As body mass index (BMI) of the PCOS patients was significantly higher than the controls (median 24.6kg/m(2) and 21.4kg/m(2), respectively, p<0.001) all parameters were evaluated after adjustment for BMI. Adolescents with PCOS had significantly higher levels of fasting glucose, insulin, HOMA-IR and granzyme-B when compared with controls. According to the results of logistic regression analysis, granzyme-B levels were found to be sign...Continue Reading

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Citations

Aug 9, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Tomoyuki Kawada
Jul 2, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Serap KaramanKamuran Karaman
Jan 14, 2020·Pakistan Journal of Biological Sciences : PJBS·Elham ZareiAzadreza Mansourian
May 11, 2019·Journal of Endocrinological Investigation·I BarchettaM G Cavallo
Jun 20, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Mecnun ÇetinAhmet Ufuk Kömüroğlu

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