PMID: 9652828Jul 4, 1998Paper

Increased levels of soluble tumour necrosis factor receptor-I (P55) and decreased IgG1 reactivities in HIV-1 patients with cytomegalovirus disease

Scandinavian Journal of Immunology
P H JakobsenP Skinhøj

Abstract

The purpose of the study was to investigate potential associations between tumour necrosis factor (TNF), soluble TNF receptors (sTNF-Rs), immunoglobulin (Ig)G subclasses and development of cytomegalovirus (CMV) disease amongst human immunodeficiency virus (HIV)-1 patients. We enrolled HIV-1 patients with CD4 counts less than 100/microl in a prospective study and followed them over 1 year for development of CMV disease. Concentrations of TNF, sTNF-RI, sTNF-RII and IgG subclass reactivities were measured by ELISA; levels of CMV pp65 antigenaemia were determined as numbers of pp65 expressing cells/100,000 cells and were measured by staining of leucocytes; and HIV-1 RNA loads were measured by polymerase chain reaction (PCR). Eighteen patients studied with CMV disease had higher levels of sTNF-RI than 18 similar patients without CMV disease. Concentrations of sTNF-RI correlated with levels of CMV antigenaemia in blood samples collected before the development of CMV disease. Patients with CMV disease had lower levels of IgG1 reactivities to CMV than patients without CMV disease. We conclude that increased levels of sTNF-RI and decreased IgG1 reactivities are associated with an increased risk of development of CMV disease among HIV-1 ...Continue Reading

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Citations

Feb 24, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·P A RomagnoliH M Serra
Apr 23, 2004·Leukemia & Lymphoma·Ross BrownDoug Joshua
Sep 25, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael L FreemanMichael M Lederman
Jun 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gloria EstesoHugh T Reyburn
Jan 5, 2021·Frontiers in Cardiovascular Medicine·Ahmad Aljohmani, Daniela Yildiz

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