Increased Levels of Txa₂ Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue

Viruses
Eneida S OliveiraCarlos E Calzavara-Silva

Abstract

The inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the Dengue virus-induced inflammatory process. To quantify the molecules involved in the cyclooxygenase and lipoxygenase pathways during Dengue virus infection, plasma levels of thromboxane A2, prostaglandin E2 and leukotriene B4; mRNA levels of thromboxane A2 synthase, prostaglandin E2 synthase, leukotriene A4 hydrolase, cyclooxygenase-2 and 5-lipoxygenase; and the levels of lipid bodies in peripheral blood leukocytes collected from IgM-positive and IgM-negative volunteers with mild dengue, and non-infected volunteers, were evaluated. Dengue virus infection increases the levels of thromboxane A2 in IgM-positive individuals as well as the amount of lipid bodies in monocytes in IgM-negative individuals. We suggest that increased levels of thromboxane A2 in IgM-positive individuals plays a protective role against the development of severe symptoms of dengue, such as vascular leakage.

References

Jun 1, 1992·Kidney International·G RemuzziC Patrono
Jun 1, 1990·The Annals of Thoracic Surgery·F M RamadanG Johnson
May 1, 1986·Oral Surgery, Oral Medicine, and Oral Pathology·R K White, S Montgomery
Jan 1, 1993·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R W WrennT H Rosenquist
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bianca RoccaCarlo Patrono
Jul 9, 2004·Journal of Biomedicine & Biotechnology·Harizi Hedi, Gualde Norbert
Apr 2, 2005·Virology Journal·Jesus A MosqueraGerman J Añez
Sep 2, 2006·Pharmacology & Therapeutics·Patricia T BozzaChristianne Bandeira-Melo
Sep 9, 2008·Trends in Molecular Medicine·Hedi HariziNorbert Gualde
Sep 25, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Iranaia Assunção-MirandaMarcelo T Bozza
Oct 14, 2009·Clinical Microbiology Reviews·Byron E E MartinaAlbert D M E Osterhaus
Oct 24, 2009·PLoS Pathogens·Marcelo M SamsaAndrea V Gamarnik
Mar 25, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rossana C N MeloPeter F Weller
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Emanuela Ricciotti, Garret A FitzGerald
May 14, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Patricia T BozzaChristianne Bandeira-Melo
Nov 18, 2011·The Journal of Biological Chemistry·Eva Herker, Melanie Ott
Dec 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pawel Kalinski
Sep 7, 2012·Advances in Virology·Nadine A Dalrymple, Erich R Mackow
Apr 9, 2013·Nature·Samir BhattSimon I Hay
Oct 31, 2013·Virology Journal·Wai Mun LokeRaymond C S Seet
Jun 27, 2015·Experimental and Molecular Pathology·Aastha JindalEmanuele Albano
Jul 4, 2015·Nature Reviews. Immunology·Edward A Dennis, Paul C Norris
Oct 16, 2015·Vaccine·Cameron P SimmonsBridget Wills
Aug 19, 2016·Nature Reviews. Disease Primers·Maria G GuzmanScott B Halstead
Oct 28, 2016·Expert Review of Anti-infective Therapy·Tau Hong LeeYee Sin Leo
Feb 1, 2017·Scientific Reports·Amrita OjhaPrasenjit Guchhait
Apr 25, 2017·Immunology·Gathsaurie Neelika Malavige, Graham S Ogg
Jun 19, 2017·Parasites & Vectors·Etiene Casagrande PacidônioLuciano Andrade Moreira
Aug 16, 2017·Journal of Neuroinflammation·Nils LannesLuis Filgueira

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
light microscopy

Software Mentioned

Sequence Detection
FlowJo
GraphPad
Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Lipid Mediators and Cell Signalling
T YokomizoT Shimizu
Advances in Experimental Medicine and Biology
H E ClaessonO Rådmark
American Journal of Respiratory and Critical Care Medicine
J Z Haeggström
Advances in Prostaglandin, Thromboxane, and Leukotriene Research
P Mené, M J Dunn
© 2022 Meta ULC. All rights reserved