PMID: 12752587May 20, 2003Paper

Increased levels of vascular endothelial growth factor in induced sputum in asthmatic patients

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
K AsaiJunichi Yoshikawa

Abstract

Vascular endothelial growth factor (VEGF) is highly expressed in the airway of asthmatic patients. As VEGF increases airway vascular permeability, consequent thickening of the airway wall mucosa may lead to narrowing of the airway lumen. We evaluated the relationship between VEGF levels in induced sputum and eosinophilic inflammatory profiles, and the degree of airway vascular permeability in asthmatic patients and we evaluated the effect of inhaled corticosteroids on VEGF levels in induced sputum. Induced sputum specimens were obtained from 28 glucocorticosteroids free asthmatics and 11 healthy control subjects. We examined VEGF levels and airway vascular permeability index in induced sputum. After the initial sputum induction, 21 asthmatics received 8-week inhaled beclomethasone dipropionate (BDP, 800 micro g/day) therapy, then sputum induction was repeated. The VEGF levels in asthmatics were significantly higher than in healthy control subjects (P < 0.0001). The VEGF levels were negatively correlated with forced expiratory volume of 1 s (FEV1, % predicted, r = - 0.68, P < 0.001), the percentage of eosinophils (r = 0.51, P < 0.01) and ECP levels (r = 0.39, P < 0.05). Moreover, the VEGF levels were significantly correlated wit...Continue Reading

References

Nov 1, 1993·The American Review of Respiratory Disease·K KuwanoJ C Hogg
May 1, 1997·The Journal of Clinical Investigation·R G TiltonJ R Williamson
May 1, 1997·The Journal of Allergy and Clinical Immunology·H KanazawaJ Yoshikawa
May 1, 1997·American Journal of Respiratory Cell and Molecular Biology·W M ManiscalcoR M Ryan
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·X Li, J W Wilson
Mar 21, 1998·The Journal of Cell Biology·S EsserW Risau
Nov 21, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H KanazawaJ Yoshikawa
Oct 16, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P DemolyJ Bousquet
Dec 12, 2000·The Journal of Allergy and Clinical Immunology·H KanazawaJ Yoshikawa
Jun 9, 2001·The Journal of Allergy and Clinical Immunology·Y C Lee, H K Lee
Sep 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·K R BrownM J Acarregui
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Elizabeth L J Van RensenPeter J Sterk

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Citations

Oct 19, 2012·Current Allergy and Asthma Reports·Norbert Meyer, Cezmi A Akdis
Aug 12, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Yun-Jeong BaeYou Sook Cho
Jan 5, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sook Young LeeYoung Kyoon Kim
Jan 13, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Hiroshi Kanazawa, Junichi Yoshikawa
Oct 5, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Hiroshi KanazawaJunichi Yoshikawa
Sep 7, 2011·Cell Research·Zhaoyuan FangHongbin Ji
Jul 11, 2006·Acta Paediatrica·Anna Wasilewska, Walentyna Zoch-Zwierz
Sep 25, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Seoung J ParkYong C Lee
Mar 28, 2007·Thorax·Alan J KnoxRachel Clifford
Oct 25, 2012·International Journal of Endocrinology·Alfredo Chetta, Dario Olivieri
Mar 27, 2004·American Journal of Respiratory and Critical Care Medicine·Hiroshi KanazawaJunichi Yoshikawa
Apr 28, 2007·American Journal of Respiratory and Critical Care Medicine·David E SimcockStuart J Hirst
Jun 17, 2008·American Journal of Respiratory and Critical Care Medicine·David E SimcockStuart J Hirst
Jul 2, 2011·American Journal of Respiratory and Critical Care Medicine·Haruki ImaokaRoma Sehmi
Jun 29, 2004·American Journal of Respiratory and Critical Care Medicine·Neil C Thomson, Rekha Chaudhuri
Nov 11, 2003·American Journal of Respiratory Cell and Molecular Biology·Clemens FeistritzerChristian J Wiedermann
Aug 22, 2007·American Journal of Respiratory Cell and Molecular Biology·Akio MatsudaHirohisa Saito
Jul 3, 2004·The Journal of Clinical Investigation·Scott S WagersCharles G Irvin
Oct 6, 2010·Respiratory Research·Andrea ZaniniDario Olivieri
Oct 19, 2006·Respiratory Research·Andriana I PapaioannouKonstantinos I Gourgoulianis
May 12, 2009·BMC Pulmonary Medicine·Andriana I PapaioannouZoe D Daniil
Aug 7, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Julie St-LaurentElyse Bissonnette
Jul 1, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Hiroshi KanazawaNobuaki Umeda
Dec 2, 2004·Expert Opinion on Emerging Drugs·Fabienne Rancé
Aug 21, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Andras BikovIldiko Horvath
Dec 3, 2014·Pharmacology & Therapeutics·Louise M HarknessJanette K Burgess
Apr 4, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Hasan YukselOzkan Karaman
Dec 17, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Tetsuo ShodaAkio Matsuda
Feb 11, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Young YooJi Tae Choung
May 5, 2009·Pulmonary Pharmacology & Therapeutics·Simon R BaileyMarkus Weckmann
Aug 8, 2007·The Journal of Allergy and Clinical Immunology·Thais MauadPeter J Sterk
Oct 13, 2007·Vascular Pharmacology·Sook Young Lee, Su-Mi Chung
Jul 6, 2007·The Journal of Allergy and Clinical Immunology·Salman SiddiquiChristopher Brightling
Nov 18, 2014·European Journal of Clinical Investigation·Vasiliki PettaStelios Loukides
Nov 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H Kanazawa, J Yoshikawa
Feb 25, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G-S ChoiH-S Park

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