Increased libido associated with donepezil treatment: a case report

Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society
Nusa SegrecPeter Pregelj

Abstract

Inappropriate verbal and physical sexual behaviour is not common among individuals with dementia, but when it does occur, it can have profound consequences. We report a case of 79-year-old woman with dementia of the Alzheimer's type who complained of increased libido after an increased dose of donepezil, which was being used along with tianeptine. Donepezil withdrawal led to the resolution of increased libido, but when it was reintroduced, increased libido reappeared once again (Naranjo score: 7). Increased libido was not reported by the patient during the 6-year follow-up period after donepezil withdrawal. A potential mechanism of acetylcholinesterase inhibitor-induced increased libido and the current literature on hypersexuality as a side-effect of donepezil treatment are discussed.

References

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Sep 9, 2005·American Journal of Therapeutics·Larry S Ivanco, Nicolaas I Bohnen
Sep 24, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giuseppe TostoGiuseppe Bruno
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Jan 9, 2013·Archives of Sexual Behavior·Mario F Mendez, Jill S Shapira

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Citations

Sep 9, 2017·Endocrinology, Diabetes & Metabolism Case Reports·Kingsley OkolieChristopher J Nolan
Oct 5, 2017·American Journal of Alzheimer's Disease and Other Dementias·Vinod KaushikMukaila A Raji
Jan 17, 2020·Dementia and Neurocognitive Disorders·Tae Hwan Yoon, Tae-Beom Ahn
Aug 20, 2021·Journal of Clinical Psychopharmacology·Poonè Haghani TehraniMohamad H Khafaja

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