Increased lipoprotein-remnant formation in chronic renal failure

The New England Journal of Medicine
P J NestelM H Tan

Abstract

Since accelerated atherosclerosis may be induced by excess circulating remnants of triglyceride-rich lipoprotein catabolism, we looked for evidence of remnant particle accumulation in the lipoproteins of 11 patients on long-term dialysis. We found several abnormalities in lipoprotein protein and lipids: enrichment of intermediate-density lipoproteins (ILD) and low-density lipoproteins (LDL) with triglyceride; the presence of apoprotein B48 (a "marker" for intestinal lipoproteins) in very-low-density lipoproteins (VLDL); an increased concentration of apoprotein AIV (a protein related to chylomicron transport); the presence of AIV in VLDL, IDL, and LDL; and the presence in LDL of apoproteins C and E (proteins not normally found in LDL). These findings strongly suggest accumulation of remnants of triglyceride-rich lipoproteins in patients with chronic renal failure who are undergoing peritoneal dialysis or hemodialysis, and may explain in part the increased incidence of coronary deaths among these patients.

References

Oct 1, 1978·European Journal of Clinical Investigation·K BolzanoF Sandhofer
Dec 1, 1975·The Journal of Clinical Investigation·J P KaneR J Havel
Aug 1, 1977·Metabolism: Clinical and Experimental·J D BrunzellD J Sherrard
Dec 22, 1977·The New England Journal of Medicine·R MordasiniH Greten
Jul 1, 1979·The Journal of Clinical Investigation·P H GreenAlan R Tall
Dec 1, 1978·The Journal of Clinical Endocrinology and Metabolism·A P GoldbergJ D Brunzell
Apr 26, 1973·The New England Journal of Medicine·E G LowrieJ P Merrill
Mar 28, 1974·The New England Journal of Medicine·A LindnerB H Scribner
May 22, 1981·Biochimica Et Biophysica Acta·N TadaG Campbell
Dec 1, 1980·European Journal of Clinical Investigation·H E Norbeck, L A Carlson
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J P KaneH E Paulus
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·K V KrishnaiahG S Getz
Apr 1, 1980·The Journal of Clinical Investigation·P H GreenE Quinet
Mar 31, 1981·Biochemical and Biophysical Research Communications·J Bell-QuintP Graham
May 14, 1980·Biochemical and Biophysical Research Communications·A van TolH Jansen

Citations

Aug 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M Antikainen
Mar 29, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jeffrey M Saland, Henry N Ginsberg
Nov 6, 2012·Molecular and Cellular Biochemistry·A OsorioE Ruiz-Requena
Jan 1, 1994·Chemistry and Physics of Lipids·M D CressmanH F Hoff
Apr 15, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Ohta, I Matsuda
Aug 31, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Seishima, Y Muto
Nov 30, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·H ShimizuT Saito
Aug 14, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·R KnöflerA Takada
Apr 15, 1995·Thrombosis Research·R KnöflerA Takada
Jan 1, 1995·Molecular Aspects of Medicine·M J Halpern
Nov 13, 2001·The American Journal of Cardiology·E J SchaeferJ J Rubenstein
Sep 18, 1998·Diabetes Research and Clinical Practice·G Steiner
Jun 13, 2001·Journal of the American College of Cardiology·P J NestelJ Chin-Dusting
Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·C D Short, P N Durrington
Nov 26, 2009·Nature Reviews. Nephrology·Florian Kronenberg
Jan 12, 2002·Kidney International·Diana M LeeP Alaupovic
May 14, 2005·Current Opinion in Lipidology·Søren K Moestrup, Lars Bo Nielsen
Aug 1, 1993·Journal of Internal Medicine·S ZambonE Manzato
Apr 1, 1992·Australian and New Zealand Journal of Medicine·S C Greaves, D N Sharpe
Mar 17, 2012·International Journal of Clinical Practice·Koichiro HommaH Itoh
Sep 1, 1985·The Journal of Clinical Investigation·T OhtaP J Nestel
Apr 24, 2004·Lipids in Health and Disease·Hassan ArganiMohammad Rahbaninobar
Dec 18, 2013·Journal of Atherosclerosis and Thrombosis·Mika SonodaMasaaki Inaba
Dec 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Y HenkinS Shany
Jan 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Rubiés-PratL Pira
Mar 1, 1997·Kidney International·N D Vaziri, K Liang
Dec 1, 1992·Kidney International·P O AttmanP Alaupovic
Sep 1, 1987·Kidney International·P O AttmanA Gustafson
Feb 1, 1993·Kidney International·J JovenJ D Brunzell
Mar 1, 1990·Kidney International·S M Grundy
Nov 1, 1992·Kidney International·M S WeintraubA Iaina
Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masaaki EtoKohei Kaku
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Evagelos LiberopoulosM S Elisaf
Feb 9, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Cheryl McFarlaneJane McEneny
Jul 24, 1991·The American Journal of Cardiology·M ManciniD Pometta
Mar 1, 1984·Progress in Cardiovascular Diseases·N B Ruderman, C Haudenschild
Nov 1, 1992·Metabolism: Clinical and Experimental·M ToborekE Kopieczna-Grzebieniak
Apr 1, 1994·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·N CanoJ P Durbec
Oct 29, 2005·Metabolism: Clinical and Experimental·René ValeroHenri Portugal
Feb 1, 2003·Journal of Atherosclerosis and Thrombosis·Eiji KimotoYoshiki Nishizawa
Oct 30, 2014·Frontiers in Endocrinology·Sandra MerscherArmando J Mendez
May 11, 2016·Kidney International·Jeffrey M SalandHenry N Ginsberg
Nov 1, 1990·Metabolism: Clinical and Experimental·G FeussnerR Ziegler
Jun 22, 2006·Journal of Lipid Research·Arno LingenhelFlorian Kronenberg
Nov 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·E ManzatoM Braggion
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M ShaikhB Lewis
Mar 1, 1992·European Journal of Clinical Investigation·H DieplingerG Utermann
Oct 1, 1989·European Journal of Clinical Investigation·M S WeintraubJ L Breslow
Feb 1, 1994·European Journal of Clinical Investigation·S HörkköY A Kesäniemi
Mar 16, 2007·Journal of the American Society of Nephrology : JASN·Bonnie C H KwanAlfred K Cheung
Nov 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Christiane L HaaseRuth Frikke-Schmidt
Jan 22, 1998·The American Journal of Physiology·N D VaziriK Liang
Sep 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Kaihui Liang, N D Vaziri
Feb 1, 1997·Scandinavian Journal of Clinical and Laboratory Investigation·M Arnadottir
Jan 1, 1993·Scandinavian Journal of Urology and Nephrology·M S ElisafK C Siamopoulos
Nov 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation·M ArnadottirP Nilsson-Ehle
Dec 25, 2015·American Journal of Physiology. Renal Physiology·Patricia WahlAlessia Fornoni
Aug 23, 2017·Expert Opinion on Therapeutic Targets·Marcelino Bermúdez-LópezJose M Valdivielso
Oct 1, 1986·Gastroenterologia Japonica·Y MiyataH Ibayashi
May 7, 2011·Molecular and Cellular Biochemistry·A OsorioE Ruiz-Requena
Jan 25, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Justyna SzostakJulia Hoeng

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