PMID: 11898805Mar 20, 2002Paper

Increased lithium dose requirement in a hyperglycemic patient

The Annals of Pharmacotherapy
Monica CyrS Casey Laizure

Abstract

To report a case of apparent increased lithium clearance in a patient with persistent hyperglycemia. Lithium doses, blood glucose concentrations, and lithium plasma concentrations were evaluated in a patient during a 53-day inpatient admission for exacerbation of bipolar disorder. The lithium dose required to increase the lithium plasma concentration by 0.1 mEq/L was computed from the lithium dose and corresponding lithium plasma concentration. This value was correlated with the blood glucose concentration. A plot of the lithium dose required to increase the lithium plasma concentration by 0.1 mEq/L versus the blood glucose concentration exhibited a direct linear relationship (r2 = 0.62). This plot indicates that higher lithium doses are needed during hyperglycemic states compared with euglycemic states to achieve equivalent plasma concentrations. Glycosuria associated with hyperglycemia induces an osmotic diuresis that increases the renal clearance of lithium, necessitating higher lithium doses to maintain therapeutic lithium plasma concentrations.

References

Oct 1, 1968·The American Journal of Physiology·K Thomsen, M Schou
Dec 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·J M ChristensenN Hollingshead
Mar 12, 1999·Journal of the American Society of Nephrology : JASN·R T Timmer, J M Sands

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Citations

Nov 26, 2009·Chemistry & Biodiversity·Gregory J AngerMicheline Piquette-Miller

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