PMID: 9183440Mar 1, 1997Paper

Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity

Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
E Le Bourg, N Minois

Abstract

In recent years, attempts have been made to increase longevity in animal models (caloric restriction in rodents or overexpression of catalase and superoxide dismutase in transgenic flies, for instance). We report here that flies submitted to hypergravity (3 or 5 g), for 1 or 4 weeks starting from the second day of imaginal life and transferred after that time to 1 g, have a higher resistance to heat shock than flies living continuously at 1 g. Furthermore, male flies that had lived for 2 weeks from the second day of life at 3 or 5 g, lived longer than those living all the time at 1 g; no longevity increase was observed in females. As far as we know, this is the first example in flies showing that a mild stress at a young age not only increases resistance to an acute stress but also increases longevity. A hypothesis to explain these results could be that heat-shock proteins, which are induced by various stress factors, are synthesized in conditions of hypergravity.

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Citations

Nov 10, 2010·Biogerontology·Tatyana A DubileyAlexander M Vaiserman
Sep 1, 2005·Age·Ronny HaenoldToshinori Hoshi
Jan 10, 2002·Mathematical Biosciences·Anatoli I Michalski, Anatoli I Yashin
Jul 16, 1999·Mechanisms of Ageing and Development·N Minois, E Le Bourg
Oct 23, 2002·Molecular and Cellular Biology·Matt KaeberleinLeonard Guarente
May 26, 2009·Biochimica Et Biophysica Acta·Eric Le Bourg
Sep 21, 2010·Ecology Letters·David CostantiniPat Monaghan
May 28, 2014·Evolution; International Journal of Organic Evolution·Colin D McClureNicholas K Priest
Jan 13, 2010·Experimental Gerontology·Anne D van DiepeningenRolf F Hoekstra
Sep 21, 2016·Journal of Proteome Research·Ravikumar HosamaniSharmila Bhattacharya
Aug 17, 2001·Human & Experimental Toxicology·E Le Bourg
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Nadège Minois
May 23, 2003·Korean Journal of Biological Sciences·H R Kim
Apr 4, 2013·G3 : Genes - Genomes - Genetics·Emily L KumimotoBing Zhang
Oct 27, 2020·Fly·Deena DamschroderRobert Wessells

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