Increased lysosomal hydrolase activity in kidney and brain from the vitamin B6-deficient developing rat

Pediatric Research
R V DiPaoloJ N Kanfer

Abstract

Between 7 and 9 postnatal days, the kidney, spleen heart, and liver from vitamin B6-deficient young either plateaued and failed to gain weight or lost weight, whereas brain continued to gain weight but at a more reduced rate than normal. The level of cofactor in kidney of experimental animals was below that of controls at all time points studied. alpha-L-Fucosidase activity was already moderately increased in deficient kidney at 3 postnatal days and remained elevated throughout the time course. beta-D-galactosidase, acid phosphatase, and hexosaminidases A and B in vitamin B6-deficient young all showed moderate increases in activities after 9 days, at one or more time points. In brain, alpha-L-fucosidase activity was increased somewhat throughout the time course, but changes in beta-D-glucuronidase, beta-D-galactosidase, alpha-D-mannosidase, acid phosphatase, and hexosaminidases A and B did not occur until after 7 postnatal days. When weights of kidney and brain were both normal, there was a marked elevation in alpha-L-fucosidase activity in these organs suggesting that this increase in enzyme activity may be a specific effect of vitamin B6 deficiency. Elevated alpha-L-fucosidase activity in kidhney may reflect alterations in fu...Continue Reading

Citations

Apr 1, 1977·The American Journal of Medicine·J B Hook, W R Hewitt
Jan 1, 1984·Molecular Aspects of Medicine·R NathS Farooqui

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.