Increased matrix metalloproteinase-8 and -9 activity in patients with infarct rupture after myocardial infarction

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Susanne W M van den BorneW Matthijs Blankesteijn

Abstract

Infarct rupture is a usually fatal complication of myocardial infarction (MI), for which no molecular mechanism has been described in humans. Experimental evidence in mouse models suggests that the degradation of the extracellular matrix by matrix metalloproteinases (MMPs) plays an important role in infarct rupture. The present study was designed to study the role of MMP-2, MMP-8, and MMP-9 in human infarct rupture. Heart samples were obtained from patients who died from infarct rupture and control MI patients. The MMP activity was determined by zymography and quantitative immunocapture activity assay. TIMP-1 levels were measured and immunohistochemistry for MMP-2 and MMP-9 was performed. The amounts of both total and active MMP-8 and MMP-9 were significantly higher in ruptured infarct tissue than in control MI tissue, but no differences in MMP-2 activity were observed. Furthermore, the number of inflammatory cells was significantly higher in the ruptured infarcts than in control infarcts. These data suggest that increased MMP-8 and MMP-9 activity in the infarct area, caused by a more prominent infiltration of inflammatory cells, contribute to infarct rupture in humans.

References

Jun 1, 1995·Journal of Molecular and Cellular Cardiology·J P CleutjensK T Weber
Jun 15, 2000·The American Journal of Pathology·E CreemersP Carmeliet
Jul 6, 2000·The Annals of Thoracic Surgery·R PrêtreM I Turina
Jun 28, 2001·The Annals of Thoracic Surgery·M H McMullanS H Hindman
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Esther E J M CreemersFrancis G Spinale
May 10, 2003·Journal of Molecular and Cellular Cardiology·R English ChapmanFrancis G Spinale
May 31, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Shunji HayashidaniAkira Takeshita
Feb 16, 2005·The Journal of Clinical Investigation·Shin-ichiro MatsumuraYasunori Okada
Jul 6, 2006·Cytokine & Growth Factor Reviews·Philippe Van Lint, Claude Libert

❮ Previous
Next ❯

Citations

Jan 10, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tibor KempfKai C Wollert
Jan 5, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Evangelos P DaskalopoulosW Matthijs Blankesteijn
Nov 15, 2011·Nature Medicine·B Julie HeMark E Anderson
Jul 7, 2009·Cardiovascular Research·Nadia Hedhli, Christophe Depre
May 31, 2013·European Heart Journal Cardiovascular Imaging·Frank M BengelKai C Wollert
Sep 13, 2012·Fibrogenesis & Tissue Repair·Kevin Cm HermansW Matthijs Blankesteijn
Jun 5, 2013·Fibrogenesis & Tissue Repair·Yonggang MaMerry L Lindsey
Nov 26, 2010·Journal of Periodontology·Eralp BuduneliTimo Sorsa
Jan 1, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Immi KormiTimo Sorsa
Feb 13, 2014·Pflügers Archiv : European journal of physiology·Yonggang MaMerry L Lindsey
Jan 24, 2016·Biochimica Et Biophysica Acta·Susanne Sattler, Nadia Rosenthal
May 29, 2012·The American Journal of Emergency Medicine·Kenan Ahmet TurkdoganMehmet Birhan Yilmaz
Jan 21, 2012·Pharmacology & Therapeutics·Xiao-Ming GaoXiao-Jun Du
Nov 24, 2011·Heart Failure Clinics·Shaina R Eckhouse, Francis G Spinale
Jul 13, 2011·Drug Discovery Today·Eline DejonckheereClaude Libert
Mar 11, 2011·Cytokine & Growth Factor Reviews·Eline DejonckheereClaude Libert
Jul 31, 2010·Journal of Cardiac Failure·Kazunori UemuraMasaru Sugimachi
Mar 27, 2010·The Journal of Surgical Research·Anna SolbergMarie-Louise Ivarsson
Sep 16, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Andrea M MarcacciniRaquel F Gerlach
Jul 1, 2009·International Journal of Experimental Pathology·Ji Ke LiHai Tian
Apr 28, 2012·Scandinavian Journal of Immunology·Hatem AlfakryTimo Sorsa
Jul 14, 2010·Journal of Clinical Laboratory Analysis·Tamara DjurićDragan Alavantić
Jul 14, 2010·Matrix Biology : Journal of the International Society for Matrix Biology·Neil A TurnerKaren E Porter
Dec 5, 2014·Journal of Zhejiang University. Science. B·Geng QianYong-an Qian
Feb 28, 2015·Current Heart Failure Reports·Hisahito Shinagawa, Stefan Frantz
Jan 20, 2012·International Journal of Cardiology·Pirkko J PussinenErkki Pesonen
Sep 13, 2011·The American Journal of Pathology·Zengxuan NongJ Geoffrey Pickering
Feb 18, 2014·Asian Cardiovascular & Thoracic Annals·Alexander E Berezin, Tatiana A Samura
Oct 16, 2009·Cardiology in Review·David C SaneRichard C Becker
Aug 14, 2009·Expert Review of Cardiovascular Therapy·Juan C Chachques
Jul 9, 2011·Heart Failure Reviews·Alison L Müller, Naranjan S Dhalla
Jul 13, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Hongmei PengNour-Eddine Rhaleb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.