Increased mdr gene expression and decreased drug accumulation in a human colonic cancer cell line resistant to hydrophobic drug

Biochemical and Biophysical Research Communications
C C ChaoS Lin-Chao

Abstract

An adriamycin-resistant human colonic cancer cell line was characterized. This clone exhibits the classical multidrug resistance (MDR) phenotype, being cross-resistant to hydrophobic drugs such as colchicine, and vinblastine. In contrast, this clone shows a normal response to DNA-damaging agents. The appearance of MDR in these cells was linked to a decreased accumulation of the drug [3H]colchicine as compared to the drug-sensitive cells. This MDR line expressed 80-100 fold increased levels of the specific 4.5-kb mdr mRNA, and a gene amplification. Our results indicate that MDR in human colonic cancer cells can result from increased expression of at least one member of the mdr gene family.

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Citations

Jul 7, 1992·Biochimica Et Biophysica Acta·D Nielsen, T Skovsgaard
Aug 22, 2000·European Journal of Biochemistry·A P JongsmaH V Westerhoff
Feb 20, 1993·International Journal of Cancer. Journal International Du Cancer·J HoskinsT F Bumol
Jan 27, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mandeep SinghIndu Pal Kaur

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