Increased mean corpuscular volume of red blood cells predicts response to metronomic capecitabine and cyclophosphamide in combination with bevacizumab

The Breast : Official Journal of the European Society of Mastology
Silvia DellapasquaMarco Colleoni

Abstract

There is an urgent need for the identification of commonly assessable predictive factors in the treatment of patients with metastatic breast cancer. During the course of a treatment including low dose metronomic oral cyclophosphamide and capecitabine plus i.v. bevacizumab (plus erlotinib in one third of the patients) for metastatic breast cancer, we observed that a relevant number of patients developed repeatedly elevated levels of mean corpuscular volume (MCV) of red blood cells without a significant fall in hemoglobin levels. We conducted a retrospective analysis on these 69 patients to evaluate if the increase in MCV could be associated to tumor response. During the course of treatment 42 out of 69 patients (61%) developed macrocytosis. Using Cox proportional hazards modeling that incorporated macrocytosis (MCV ≥ 100 fl) as a time-dependent covariate, macrocytosis resulted in a halved risk of disease progression (HR 0.45; 95% CI, 0.22-0.92, p-value 0.028). In a landmark analysis limited to patients with no sign of progression after 24 weeks of treatment, median time to progression was 72 weeks (48 weeks after landmark) in patients who had developed macrocytosis, and 43 weeks (19 weeks after landmark) in patients who had not ...Continue Reading

References

Sep 1, 1972·British Journal of Haematology·A V Hoffbrand, A H Waters
Feb 21, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R K GregoryS Ashley
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M MiwaH Ishitsuka
Sep 3, 2002·Computer Methods and Programs in Biomedicine·Rodolphe ThiébautDaniel Commenges
Oct 3, 2002·Nature Reviews. Cancer·Robert Kerbel, Judah Folkman
Jun 2, 2004·Nature Reviews. Cancer·Robert S Kerbel, Barton A Kamen
Aug 4, 2004·American Journal of Clinical Oncology·Constantine J KarvellasJohn R Mackey
Sep 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Silvia DellapasquaMarco Colleoni

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Citations

Sep 27, 2012·Journal of Mammary Gland Biology and Neoplasia·Robert S Kerbel
Jun 11, 2014·Nature Reviews. Clinical Oncology·Nicolas AndréEddy Pasquier
Sep 17, 2014·Biomarkers in Medicine·Gemma CramarossaUrban Emmenegger
Oct 17, 2015·Anti-cancer Drugs·Michela RobertoPaolo Marchetti
Aug 5, 2015·Nature Reviews. Clinical Oncology·Elisabetta Munzone, Marco Colleoni
Apr 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Oktay BozkurtMetin Ozkan
Apr 15, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sebastiano ButiAndrea Ardizzoni
Jul 8, 2014·Cancer Treatment Reviews·Emilia MontagnaMarco Colleoni
Oct 19, 2016·Nature Reviews. Clinical Oncology·Guido Bocci, Robert S Kerbel
Jan 16, 2018·Technology in Cancer Research & Treatment·Yu-Jen ChenChen-Hsi Hsieh

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