Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish

Scientific Reports
Santiago SuniagaBjörn Busse

Abstract

Exercise promotes gain in bone mass through adaptive responses of the vertebrate skeleton. This mechanism counteracts age- and disease-related skeletal degradation, but remains to be fully understood. In life sciences, zebrafish emerged as a vertebrate model that can provide new insights into the complex mechanisms governing bone quality. To test the hypothesis that musculoskeletal exercise induces bone adaptation in adult zebrafish and to characterize bone reorganization, animals were subjected to increased physical exercise for four weeks in a swim tunnel experiment. Cellular, structural and compositional changes of loaded vertebrae were quantified using integrated high-resolution analyses. Exercise triggered rapid bone adaptation with substantial increases in bone-forming osteoblasts, bone volume and mineralization. Clearly, modeling processes in zebrafish bone resemble processes in human bone. This study highlights how exercise experiments in adult zebrafish foster in-depth insight into aging-related bone diseases and can thus catalyze the search for appropriate prevention and new treatment options.

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Citations

Apr 18, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Imke A K FiedlerBjörn Busse
Feb 2, 2019·Journal of Morphology·Andy J TurkoEmily M Standen
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Apr 4, 2020·Journal of Fish Biology·Jan Willem BekAndy Willaert
May 10, 2020·Journal of Fish Biology·Deepak Kumar Khajuria, David Karasik
Sep 27, 2018·Frontiers in Endocrinology·Paula Suarez-BreguaJosep Rotllant
Dec 13, 2019·BioMed Research International·Marta CarnovaliMassimo Mariotti
Dec 21, 2019·Journal of Fish Biology·Alice PrintziGeorge Koumoundouros
Aug 23, 2020·Cells·Maria Teresa ValentiLuca Dalle Carbonare
Aug 28, 2020·Frontiers in Endocrinology·Francesca TonelliAntonella Forlino
May 8, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Emilie DambroiseLaurence Legeai-Mallet
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Aug 3, 2021·The Journal of Experimental Biology·Paule DagenaisAnna Jaźwińska

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Methods Mentioned

BETA
X-ray
Fluorescence microscopy
electron microscopy
light microscopy

Software Mentioned

Visual SI Advanced
NRecon
OsteoMeasure
CTAn
SPSS

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