Increased messenger RNA expression of vascular endothelial growth factor and its receptors in the implantation site of the human oviduct with ectopic gestation

Fertility and Sterility
Po Mui LamChristopher Haines

Abstract

To compare the mRNA expression of vascular endothelial growth factor (VEGF) and its receptors (KDR and flt-1) in the implantation and nonimplantation sites of the human oviduct with ectopic gestation. Prospective observational study. University-based Obstetrics and Gynecology Department. Ten women undergoing laparoscopic salpingectomy for tubal pregnancy. The mucosal layer was isolated from the implantation and nonimplantation sites of the oviduct tissue with ectopic gestation. Semiquantitative reverse transcriptase-polymerase chain reaction was performed. The differences in the mRNA expression of VEGF and its receptors between the implantation and nonimplantation sites of the oviduct tissue. The mRNA expression of VEGF and its receptors, both KDR and flt-1, was significantly higher in the implantation site of the human oviduct with ectopic gestation compared with the nonimplantation site. The results suggest that VEGF may be the angiogenic factor responsible for the implantation and placentation of an ectopic pregnancy in the oviduct.

References

Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·B OlofssonU Eriksson

❮ Previous
Next ❯

Citations

Jan 15, 2010·Human Reproduction Update·J L V ShawA W Horne
Apr 19, 2012·Clinical Obstetrics and Gynecology·Mary E Rausch, Kurt T Barnhart
Nov 5, 2010·The Journal of Clinical Endocrinology and Metabolism·Andrew W HorneHilary O D Critchley
Apr 6, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Juan Manuel Corpa
Jan 9, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ikbal KaygusuzHasan Kafali
Feb 4, 2016·International Journal of Molecular Sciences·Ji-Long Liu, Miao Zhao
Mar 14, 2013·Expert Opinion on Medical Diagnostics·Shannon ReidGeorge Condous
Aug 11, 2011·Molecular and Cellular Endocrinology·Julie L V Shaw, Andrew W Horne
Feb 9, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Hiroko ItohHisashi Narahara
Nov 2, 2013·Anatomy & Cell Biology·Elham YousefianEmadeddin Yazdani Kachouei
Nov 16, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Huan JiangWei-Jie Zhu
Oct 21, 2019·Metabolomics : Official Journal of the Metabolomic Society·Onur TurkogluRay O Bahado-Singh
Feb 24, 2011·Obstetrics and Gynecology·Mary E RauschKurt T Barnhart
Jun 21, 2012·Molecular and Cellular Biochemistry·Jian-Ying XuHuan Jiang
Dec 20, 2005·Fertility and Sterility·Po Mui Lam, Christopher Haines

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.