PMID: 8613679Mar 1, 1996Paper

Increased micronucleus frequency in the progeny of irradiated Chinese hamster cells

International Journal of Radiation Biology
M Jamali, K R Trott

Abstract

V79 Chinese hamster cells were irradiated with doses of 1-12 Gy 300 kV X-rays. Their colony-forming ability and the frequency of micronuclei in binucleate cells after treatment with cytochalasin B was determined at various times after irradiation. The frequency of micronuclei determined within the first 24 h after irradiation increased with doses up to 4 Gy and decreased as the dose increased further. Up to 4 Gy there was a close correlation between surviving fraction and the fraction of cells without micronuclei although the surviving fraction was 2-3 times lower than the fraction of cells without micronuclei. Six, 10 or 13 days after irradiation with either 9 or 12 Gy the plating efficiency and the frequency of micronuclei after cytokinesis block with cytochalasin B was determined in the irradiated, but surviving, cells. The delayed plating efficiency of irradiated cells was significantly decreased. The proportion of binucleated cells was in the normal range at 6-13 days after irradiation, indicating that the proliferative activity of irradiated but surviving cells was not depressed at that time. The micronucleus frequency, however, was significantly increased at all times after irradiation. There was little heterogeneity of ...Continue Reading

References

Feb 1, 1991·International Journal of Radiation Biology·U Weissenborn, C Streffer
Sep 1, 1991·International Journal of Radiation Biology·W P Chang, J B Little
Nov 1, 1989·International Journal of Radiation Biology·E O WandlK Höbarth
Nov 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·N J McNallyM Hinchliffe
Aug 1, 1980·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J Midander, L Révész
Apr 1, 1981·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S J GroteC A Shaw
Mar 1, 1995·International Journal of Radiation Biology·M AbendD Van Beuningen
Nov 1, 1994·International Journal of Radiation Biology·A Kronenberg
Aug 1, 1994·International Journal of Radiation Biology·D C Brown, K R Trott
Nov 1, 1993·Molecular and Cellular Biology·B A Marder, W F Morgan

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Citations

Mar 16, 2007·International Journal of Radiation Biology·A SeoaneF Dulout
Dec 1, 1996·International Journal of Radiation Biology·M Jamali, K R Trott
Jan 9, 1999·International Journal of Radiation Biology·K R TrottA Teibe
Mar 10, 2006·International Journal of Radiation Biology·Zsolt SomodiKevin M Prise
Sep 3, 2014·Biomedical Journal·Shrikant L PatilK P Rajashekhar
Jan 15, 2008·Radiation and Environmental Biophysics·Otilia Nuta, Firouz Darroudi
May 7, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Katriina HuumonenJukka Juutilainen
Jan 1, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Jukka LuukkonenJonne Naarala
Feb 26, 2016·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Julie J BurttRobert M Lafrenie
Jul 11, 2003·Health Physics·Leslie E SmithWilliam F Morgan

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