Increased micronucleus frequency in phytohaemagglutinin-stimulated blood cells of patients with vitiligo

Journal of the European Academy of Dermatology and Venereology : JEADV
H Donmez-AltuntasH Demirtas

Abstract

Vitiligo is a relatively common, acquired pigmentary disorder characterized by areas of depigmented skin resulting from loss of melanocytes in the epidermis. Although several hypotheses have been proposed for the aetiology and pathogenesis of vitiligo, the cause of vitiligo remains unclear. To evaluate spontaneous micronucleus (MN) frequency using the cytokinesis block MN assay to determine damages at the DNA or chromosome level in phytohaemagglutinin (PHA)-stimulated blood cells of patients with vitiligo and healthy control subjects. Peripheral blood samples were obtained and cultured from 21 patients with vitiligo (mean age: 21.48 +/- 9.78 years) and 21 age- and sex-matched healthy control subjects (mean age: 21.52 +/- 9.80 years). MN values were scored in binucleated cells obtained from whole-blood cultures of patients and control subjects. MN frequencies (mean +/- SD) in PHA-stimulated blood cells of patients with vitiligo and control subjects were 0.94 +/- 0.58 and 0.58 +/- 0.32, respectively. Compared with control subjects, MN frequencies of patients with vitiligo were found significantly higher than those of the control subjects (P = 0.012). Our results indicate unexpectedly some chromosomal/DNA damage in whole-blood cul...Continue Reading

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Citations

Sep 5, 2015·BioMed Research International·Olivia Torres-BugarínMaría Guadalupe Zavala-Cerna
Jun 13, 2020·Frontiers in Veterinary Science·María Evarista Arellano-GarcíaOlivia Torres-Bugarín

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