Jan 1, 1976

Increased microvascular permeability to plasma proteins in short- and long-term juvenile diabetics

Diabetes
H H Parving

Abstract

The present findings of increased microvascular protein passage are compatible with the hypothesis that the organic, histologically demonstrated diabetic microangiopathy is a long-term effect of periods of increased extravasation of plasma proteins, with subsequent protein deposition in the microvascular wall, i.e., the concept of plasmatic vasculosis. Arterial hypertension, frequently present in diabetes, enhances the development of arteriolar hyalinosis. Effective treatment of diabetes and hypertension arrests development of the microvascular lesions.

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Mentioned in this Paper

Hyalinosis, Systemic
Pulmonary Arterial Hypertension
Protein Deposition
Extravasation
Diastolic Blood Pressure
Serum Proteins
Permeability
Glucose, (beta-D)-Isomer
Plasma Proteins
Blood

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