Increased monocyte turnover is associated with interstitial macrophage accumulation and pulmonary tissue damage in SIV-infected rhesus macaques

Journal of Leukocyte Biology
Yanhui CaiMarcelo J Kuroda

Abstract

We recently reported that increasing blood monocyte turnover that was associated with tissue macrophage death better predicts terminal disease progression in adult SIV-infected macaques than does declining CD4(+) T cell levels. To understand better mechanisms of pathogenesis, this study relates severity of lung-tissue damage to the ratio, distribution, and inflammatory responses of lung macrophage subsets during SIV infection in rhesus macaques exhibiting varying rates of monocyte turnover. In vivo BrdU incorporation was used to evaluate kinetics of monocyte/tissue macrophage turnover. Tissue damage was scored microscopically from H&E-stained lung-tissue sections, and cytokine expression was examined via immunohistochemistry and confocal microscopy. Increased monocyte turnover in SIV-infected rhesus macaques significantly correlated with severity of lung-tissue damage, as exhibited by perivasculitis, vasculitis, interstitial pneumonia, alveolar histiocytosis, foamy macrophages, multinucleated giant cells, fibrin, and edema in the alveoli. In addition, the higher monocyte turnover correlated with declining AI ratio, increased accumulation of IM in the perivascular region of the lung, and higher expression of IL-6 in the IM of th...Continue Reading

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Citations

May 2, 2015·PloS One·Yue LiQingsheng Li
Feb 13, 2018·The Journal of Infectious Diseases·Nargis Khan, Maziar Divangahi
Mar 31, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naofumi TakahashiMarcelo J Kuroda
Jul 10, 2019·Journal of Leukocyte Biology·Daniel I PetkovMarcelo J Kuroda
Oct 11, 2019·Physiological Reviews·Sushma K CribbsAlison Morris
Jun 25, 2020·International Journal of Molecular Sciences·Przemyslaw WielgatHalina Car
Oct 4, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yanhui CaiMarcelo J Kuroda
Jul 8, 2020·Viruses·Hisashi Akiyama, Suryaram Gummuluru
Dec 22, 2020·Cytokine & Growth Factor Reviews·Marina DukhinovaAnna Shtro

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