Increased mortality in chronic kidney disease: a call to action

The American Journal of the Medical Sciences
Mark A Perazella, Samina Khan

Abstract

The mortality rate among patients with chronic kidney disease is much higher than among those without. As glomerular filtration rate declines and patients approach end-stage renal disease, the mortality rate increases and patients at this stage are more likely to die than receive renal replacement therapy. The higher mortality and its underlying causes among chronic kidney disease patients is a serious issue. Lack of physician awareness of chronic kidney disease and its association with excess mortality remains a problem. In this review of current literature, we aim to increase this awareness among health care professionals and the general public and to call for action to improve survival in chronic kidney disease patients. The data strongly suggest that advancing kidney dysfunction leads to increased mortality risk. Contributing to the mortality associated with chronic kidney disease are the comorbidities that accompany this disease state. For instance, patients with chronic kidney disease and comorbidities are at 1.3 to 3.6 times more risk than patients without chronic kidney disease. Further, cardiovascular disease is the leading cause of death among chronic kidney disease patients. It appears that both traditional (such as ...Continue Reading

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Citations

Mar 3, 2012·QJM : Monthly Journal of the Association of Physicians·X ShengL Wei
Aug 12, 2008·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Arif MutwaliDonal Reddan
Jun 10, 2010·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Hugh GallagherChristopher Cates
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Sep 23, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sharlene A GreenwoodHugh S Cairns
Aug 26, 2014·BioMed Research International·Ranganathan NatarajanSubodh J Saggi
May 6, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Colin Thomas WhiteMina Matsuda-Abedini
Nov 15, 2018·Ciência & saúde coletiva·Thatiana Lameira Maciel AmaralGina Torres Rego Monteiro
Sep 22, 2017·BioMed Research International·Hongchang YangMin Wang
Apr 4, 2014·Current Opinion in Nephrology and Hypertension·Mark K ElliottDamian G Fogarty
Jun 13, 2019·International Journal of Nephrology·Innocent Ijezie ChukwuonyeEfosa Oviasu

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