DOI: 10.1101/19009621Oct 22, 2019Paper

Increased Mortality in Patients with Standard EEG Findings of \"Diffuse Slowing\"

MedRxiv : the Preprint Server for Health Sciences
Robert J WanzekGen Shinozaki


Background/Objectives: We aim to confirm the association between the high risk score on bispectral electroencephalogram (BSEEG) and mortality by comparing outcomes for those with "diffuse slowing" and normal findings on standard EEG. Design: This is a retrospective study conducted with patient chart data from March 2015 to March 2017. Setting: Single center study at a tertiary care academic hospital in the Midwest region of the USA. Participants: 1069 subjects aged 55 years and older who were on an inpatient floor or intensive care unit and received a standard 24-hour EEG. Measurements: Primary outcome was all-cause mortality at 30-, 90-, 180-, and 365- days. Secondary outcomes were time-to-discharge, and discharge to home. Results: Patients with "diffuse slowing" on standard EEG was significantly associated with 30-, 90-, 180-, and 365-day mortality (P < .001) compared to those with normal EEG findings when controlling for age, sex, and Carlson Comorbidity Index. Those with diffuse slowing also had a longer time to discharge (P < 0.001) and were less likely to discharge to home (P < 0.001) when controlling for the same factors. Findings were similar when limiting the study to only patients whose clinical status indicated "awak...Continue Reading

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