Increased motor unit potential shape variability across consecutive motor unit discharges in the tibialis anterior and vastus medialis muscles of healthy older subjects

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Maddison L HouriganTimothy J Doherty

Abstract

To study the potential utility of using near fiber (NF) jiggle as an assessment of neuromuscular transmission stability in healthy older subjects using decomposition-based quantitative electromyography (DQEMG). The tibialis anterior (TA) and vastus medialis (VM) muscles were tested in 9 older men (77 ± 5 years) and 9 young male control subjects (23 ± 0.3 years). Simultaneous surface and needle-detected electromyographic (EMG) signals were collected during voluntary contractions, and then analyzed using DQEMG. Motor unit potential (MUP) and NF MUP parameters were analyzed. NF jiggle was significantly increased for both the TA and VM in the old age group relative to the younger controls (P<0.05). NF jiggle was significantly higher in the TA compared to VM (P<0.05). For TA, NF jiggle was negatively correlated with MUNE, and positively correlated with S-MUP amplitude, NF count, MUP duration, MUP peak-to-peak voltage, and MUP area (P<0.05). For VM, NF jiggle was positively correlated with NF count and MUP area (P<0.05), and no significant correlations were found between NF jiggle and S-MUP amplitude, MUP duration, or MUP peak-to-peak voltage (MUNE was not calculated for VM, so no correlation could be made). Healthy aging is associat...Continue Reading

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Citations

Dec 17, 2015·Biogerontology·Mathew PiaseckiJamie S McPhee
Jul 21, 2015·Experimental Gerontology·Neal B McKinnonTimothy J Doherty
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Oct 6, 2017·Muscle & Nerve·Kevin J GilmoreCharles L Rice
Jun 27, 2019·Journal of Neurophysiology·Eric A KirkCharles L Rice
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Oct 4, 2019·Muscle & Nerve·Mark B Bromberg
Mar 19, 2020·Journal of Clinical Medicine·Riccardo BorzuolaAndrea Macaluso
Sep 1, 2016·Muscle & Nerve·Kevin J GilmoreCharles L Rice
Dec 18, 2020·Frontiers in Molecular Neuroscience·Yomna Badawi, Hiroshi Nishimune
Mar 29, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mathew PiaseckiDaniel W Stashuk
Oct 29, 2021·Journal of Applied Physiology·Jacques Duchateau, Roger M Enoka

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