PMID: 9546581Apr 18, 1998Paper

Increased mRNA expression of cardiac renin-angiotensin system and collagen synthesis in spontaneously hypertensive rats

Molecular and Cellular Biochemistry
H SanoH Kawaguchi

Abstract

Hypertensive cardiac hypertrophy is associated with the accumulation of collagen in the myocardial interstitium. Previous studies have demonstrated that this myocardial fibrosis accounts for impaired myocardial stiffness and ventricular dysfunction. Although cardiac fibroblasts are responsible for the synthesis of fibrillar collagen, the factors that regulate collagen synthesis in cardiac fibroblasts are not fully understood. We investigated the effects of angiotensin II on cardiac collagen synthesis in cardiac fibroblasts. Cardiac fibroblasts of 10 week old spontaneously hypertensive rats and age-matched Wistar-Kyoto rats were prepared and maintained in culture medium supplemented with 10% fetal calf serum. The expression of mRNA of the renin-angiotensin system (renin, angiotensinogen, angiotensin converting enzyme) was determined by using a ribonuclease protection assay. Basal collagen synthesis in cardiac fibroblasts from spontaneously hypertensive rats was 1.6 fold greater than that in the cell of Wistar-Kyoto rats. Angiotensin II stimulated collagen synthesis in cardiac fibroblasts in a dose-dependent manner. The responsiveness of collagen production to angiotensin II was significantly enhanced in cardiac fibroblasts from ...Continue Reading

Citations

Aug 6, 2004·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Mazen KurdiGiampiero Bricca
Sep 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·Wei XiangYan Chun Li
Jun 22, 2016·The Journal of Physiological Sciences : JPS·Fahimeh Dorri MashhadiFatemeh Safari
Jun 12, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Tassia Santos Rodrigues da CostaLisete Compagno Michelini
Mar 25, 2005·Molecular and Cellular Biochemistry·Mazen KurdiGiampiero Bricca
Mar 23, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Tomomi MatsuuraMasataka Sata
May 23, 2009·Pharmacology & Therapeutics·Karen E Porter, Neil A Turner

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