Increased mRNA expression of transforming growth factor beta in the arterial wall of chronically rejected renal allografts in humans

Transplantation Proceedings
J ZegarskaB Ziarkiewicz-Wroblewska

Abstract

Transforming growth factor beta (TGF-beta) has an established role in interstitial damage of renal transplants during chronic rejection (CR). However, its involvement in transplant vasculopathy is not clear. The aim of the study was to assess TGF-beta gene expression in the walls of large-caliber arteries within chronically rejecting renal allografts. We evaluated associations between gene expression of this factor and intimal thickness or clinical data. Renal artery samples of kidney allografts were obtained from 20 hemodialysis patients with end-stage renal graft disease due to CR, who were undergoing graftectomy. The control group included 32 hemodialysis patients with end-stage renal disease, undergoing nephrectomy due to autosomal dominant polycystic kidney disease (n = 12), chronic pyelonephritis (n = 13), or kidney limited tumor (n = 7). Gene expression of TGF-beta was measured using real-time PCR. TGF-beta mRNA expression was 3.25-fold higher in CR than in control patients (P < .001). Expression of mRNA for this cytokine was not influenced by the following factors: intimal thickness; age; serum cholesterol, triglycerides and glucose; BMI; graft survival; time of dialysis before transplantation; total ischemic time; immu...Continue Reading

Citations

Nov 4, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Geraldine RousvoalDominic C Borie
Jul 8, 2010·Journal of Cellular Biochemistry·Vojislav JovanovicSophie Brouard
Jun 13, 2012·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ming CaoDonghai Lin
Jul 15, 2017·Annals of Surgical Treatment and Research·Jung-Hwa RyuSeung-Jung Kim

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