PMID: 9160583Jan 1, 1994Paper

Increased mRNA for corticotrophin releasing hormone in the amygdala of fawn-hooded rats: a potential animal model of anxiety

Anxiety
M AltemusD L Murphy

Abstract

Compared to the outbred Wistar rat strain, the Fawn-hooded rat strain has several characteristics which suggest that the Fawn-hooded strain is hyperaroused. Fawn-hooded rats exhibit more freezing behavior in response to stress, have an increased preference for alcohol, develop adult onset hypertension, and have elevated urinary catecholamine levels. We used quantitative in situ hybridization to investigate central components of the corticotropin releasing hormone (CRH), arginine vasopressin (AVP) and noradrenergic stress response and arousal systems in these rats. We also measured basal corticosterone levels and adrenal weights to assess tonic hypothalamic-pituitary-adrenal axis activity. Compared to Wistar rats, Fawn-hooded rats had significantly increased CRH mRNA in the central nucleus of the amygdala and reduced CRH mRNA in the paraventricular nucleus of the hypothalamus. Fawn-hooded rats also bad reduced AVP mRNA expression in the parvocellular cells of the hypothalamic paraventricular nucleus. There were no differences between strains in glucocorticoid receptor mRNA in the hippocampus or the paraventricular nucleus or in mineralocorticoid receptor mRNA in the hippocampus. There was also no difference between strains in ty...Continue Reading

References

Jul 1, 1979·Journal of Studies on Alcohol·K J Drewek, P L Broadhurst
Jan 1, 1992·Annual Review of Neuroscience·M Davis
Nov 15, 1991·Biological Psychiatry·R YehudaJ W Mason
Jun 1, 1990·The American Journal of Psychiatry·M G KushnerB D Beitman
Jul 1, 1989·Brain Research. Molecular Brain Research·M C PepinN Barden
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B GrimaJ Mallet
Mar 1, 1985·Pharmacology, Biochemistry, and Behavior·G A GudelskyH Y Meltzer
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·K P Satinder, G E Wooldridge
Mar 1, 1986·Clinical and Experimental Pharmacology & Physiology·M H KuijpersW de Jong
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R Ivell, D Richter
Apr 1, 1980·Journal of Comparative and Physiological Psychology·R M Swenson, W Randall
Nov 1, 1994·Pharmacology, Biochemistry, and Behavior·C S AulakhD L Murphy
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·E PotterW Vale
Apr 1, 1993·Frontiers in Neuroendocrinology·F A Antoni
Aug 10, 1993·European Journal of Pharmacology·C S AulakhD L Murphy
Oct 1, 1992·Journal of Neuroendocrinology·M F DallmanC S Cascio

❮ Previous
Next ❯

Citations

Feb 20, 2008·Brain Structure & Function·Hilary R Smith, Linda J Porrino
Feb 26, 2003·European Journal of Pharmacology·S Mechiel Korte, Sietse F De Boer
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
Mar 10, 2001·Physiology & Behavior·S KantorG Bagdy
Sep 25, 1998·Physiology & Behavior·M Imamura, C Prasad
Apr 27, 2001·Neuroscience and Biobehavioral Reviews·S M Korte
Feb 28, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S KantorG Bagdy
Aug 12, 2006·Hormones and Behavior·Tracy L Bale
May 31, 2003·Stress : the International Journal on the Biology of Stress·R Landgraf, A Wigger
Feb 2, 2013·Pulmonary Circulation·Mita DasJames West
Jul 9, 2010·Folia Parasitologica·Joanne P Webster, Glenn A McConkey
Jul 27, 2021·Neurobiology of Stress·Maria Sanchís-OlléAntonio Armario

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.