PMID: 8610106Apr 2, 1996Paper

Increased mRNA levels for components of the lysosomal, Ca2+-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients

Proceedings of the National Academy of Sciences of the United States of America
O MansoorDidier Attaix

Abstract

The cellular mechanisms responsible for enhanced muscle protein breakdown in hospitalized patients, which frequently results in lean body wasting, are unknown. To determine whether the lysosomal, Ca2+-activated, and ubiquitin-proteasome proteolytic pathways are activated, we measured mRNA levels for components of these processes in muscle biopsies from severe head trauma patients. These patients exhibited negative nitrogen balance and increased rates of whole-body protein breakdown (assessed by [13C]leucine infusion) and of myofibrillar protein breakdown (assessed by 3-methylhistidine urinary excretion). Increased muscle mRNA levels for cathepsin D, m-calpain, and critical components of the ubiquitin proteolytic pathway (i.e., ubiquitin, the 14-kDa ubiquitin-conjugating enzyme E2, and proteasome subunits) paralleled these metabolic adaptations. The data clearly support a role for multiple proteolytic processes in increased muscle proteolysis. The ubiquitin proteolytic pathway could be activated by altered glucocorticoid production and/or increased circulating levels of interleukin 1beta and interleukin 6 observed in head trauma patients and account for the breakdown of myofibrillar proteins, as was recently reported in animal s...Continue Reading

References

Jun 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K LundholmT Scherstén
Jan 10, 1991·Nature·M GlotzerM W Kirschner
Mar 1, 1989·Diabetes/metabolism Reviews·E J Barrett, R A Gelfand
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·N AgellM J Schlesinger
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P L FaustJ M Chirgwin
Apr 1, 1984·Journal of Neurosurgery·G L CliftonC Garza
Jan 1, 1995·Molecular Biology Reports·R G TaylorA Ouali
Jan 1, 1994·Reproduction, Nutrition, Development·D AttaixL Voisin
Feb 6, 1995·Biochemical and Biophysical Research Communications·T TsujinakaM Monden
Oct 7, 1994·Cell·A Ciechanover

❮ Previous
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Citations

Jun 14, 2005·Pflügers Archiv : European journal of physiology·Samantha A WhitmanMichael P Godard
Nov 8, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vik R Rajan, William E Mitch
Jun 29, 2005·The International Journal of Biochemistry & Cell Biology·Jie DuWilliam E Mitch
Mar 24, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Maria KlaudeJan Wemerman
Mar 12, 2004·Metabolism: Clinical and Experimental·Irwin G BrodskySheryl Bedno
Nov 15, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·C PolgeD Attaix
Apr 30, 1998·Journal of the Neurological Sciences·H UeyamaT Tsuda
Oct 1, 1996·Baillière's Clinical Endocrinology and Metabolism·K Smith, M J Rennie
Oct 1, 1996·Baillière's Clinical Endocrinology and Metabolism·J WernermanP Essén
Dec 20, 2000·The Journal of Nutritional Biochemistry·S E Samuels, D Attaix
Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·Lydie CombaretDidier Attaix
Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·S R Price
May 25, 2002·European Journal of Clinical Investigation·E LöfbergA Alvestrand
Aug 3, 2002·European Journal of Clinical Investigation·R G RobertsT H J Goodship
Mar 29, 2002·Kidney International·Warren P PickeringJohn Walls
Dec 19, 1996·The New England Journal of Medicine·W E Mitch, A L Goldberg
Apr 29, 2010·The Journal of Biological Chemistry·Xiaonan H WangJie Du
Jun 1, 1999·Nutrition Research Reviews·J C Waterlow
May 12, 2001·The British Journal of Nutrition·B LöhrkeH Hagemeister
Feb 12, 2008·Journal of Neurotrauma·Christophe MoinardChristine Charrueau
Nov 29, 2012·Journal of Neurotrauma·Christophe MoinardChristine Charrueau
Jan 5, 2001·Annals of Surgery·P O Hasselgren, J E Fischer
Mar 21, 2002·Critical Care Medicine·David M Steinhorn, Satish Kalhan
Mar 5, 2003·Annals of Surgery·Maurizio BossolaFrancesco Maria Baccino
Sep 18, 2002·Kidney International·Kayser CaglarT Alp Ikizler
Jul 7, 2009·Annual Review of Nutrition·Harold A Franch, William E Mitch
Jul 25, 2009·American Journal of Physiology. Cell Physiology·Wei LiMichael B Reid
Aug 22, 2002·The Journal of Clinical Investigation·William E Mitch
Nov 30, 2000·Critical Care : the Official Journal of the Critical Care Forum·C Weissman
May 1, 2010·Journal of the American Society of Nephrology : JASN·Junping HuXiaonan H Wang
Apr 21, 2012·Advances in Nutrition·John W CarboneStefan M Pasiakos
Jul 17, 2001·Biochemical and Biophysical Research Communications·A S Whitehouse, M J Tisdale
Apr 5, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Marzena TylickaHalina Ostrowska
Jul 6, 2010·European Journal of Applied Physiology·T van WesselR T Jaspers
Dec 17, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Beau D ReillyCraig E Franklin
Jul 27, 2002·Adverse Drug Reactions and Toxicological Reviews·David Mantle, Victor R Preedy

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