Increased mutagenicity of chromium compounds by nitrilotriacetic acid

Environmental Mutagenesis
N LoprienoA G Levis

Abstract

Nitrilotriacetic acid trisodium salt (NTA), which is a substitute for polyphosphates in household laundry detergents, and N-nitrosoiminodiacetic acid (NIDA), a derivative of NTA produced by metabolism of soil microorganisms, were tested for in vitro mutagenicity in bacteria and yeasts. No gene reversions in five strains of Salmonella typhimurium (TA 1535, TA1537, TA1538, TA98, and TA100), no forward gene mutations in Schizosaccharomyces pombe P1, and no mitotic gene conversions at two loci in Saccharomyces cerevisiae D4 were induced by NTA (up to 870 micrograms/plate or 40 micrograms/ml) and NIDA (up to 2,000 micrograms/plate or 1,000 micrograms/ml), independently of the presence of rat liver metabolic activation. The influence of NTA on the mutagenic and clastogenic activity of several chromium compounds was examined in the Salmonella/microsome assay and in the sister chromatid exchange (SCE) assay in mammalian cell cultures (Chinese hamster ovary [CHO] line). NTA does not affect the genetic inactivity of water-soluble Cr(III) (Cr2[SO4]3) and the direct mutagenicity of soluble Cr(VI) (Na2CrO4,K2Cr2O7) compounds. The very insoluble Cr(VI) compounds PbCrO4 and PbCrO4 X PbO are instead clearly mutagenic in the Salmonella/microsom...Continue Reading

References

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Citations

Mar 1, 1990·Mutation Research·S De FloraP Zanacchi
Sep 1, 1993·Mutation Research·J D TuckerA V Carrano
Jan 1, 1987·Journal of Toxicology and Environmental Health·A MontaldiA G Levis
Jan 1, 1988·Journal of Toxicology and Environmental Health·G LanfranchiA G Levis
May 2, 2008·Environmental and Molecular Mutagenesis·Fabrice NesslanyDaniel Marzin
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Related Concepts

Acetic Acids
Chromium
Cricetulus
Drug Augmentation
Cricetus
Mutagenicity Tests
Clastogens
Trisodium Nitrilotriacetate
Salmonella typhimurium LT2
Sister Chromatid Exchange

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