Increased myocardial infarct size by thiopental after coronary occlusion in the dog

American Heart Journal
B I JugduttL C Becker

Abstract

The effect of a single dose (10 mg/kg) of intravenous thiopental (TP), during acute myocardial infarction, on infarct size was studied in conscious dogs randomized 10 minutes after left circumflex coronary artery occlusion to either the TP group (n = 10) or a control group given 0.9% saline solution (n = 10). During the first hour following therapy, myocardial blood flow (microspheres), arterial pressure, left atrial pressure, and arterial blood gases were similar in the two groups, but the heart rate (140 +/- 3 vs 110 +/- 3 bpm; p less than 0.001) and rate-pressure product (15,090 vs 12,210 bpm X mm Hg; p less than 0.025) were greater in the TP group. Infarct size (planimetry) and occluded bed size (postmortem coronary arteriography) measured 2 days later revealed that: the slope of the relation between infarct and occluded bed mass, as a percentage of the left ventricle (% LV) was greater with TP than with saline solution (1.10 vs 0.61; p less than 0.001); excluding hearts (four TP and three saline solution) with small occluded beds (less than 22% LV), infarcts were also larger with TP (n = 6) than with saline solution (n = 7), both as a percentage of the left ventricle (26.4 vs 12.2%; p less than 0.02) or occluded bed (61.5 ...Continue Reading

References

Dec 1, 1979·Circulation·P Scheinberg
Jul 1, 1978·Critical Care Medicine·P SafarJ V Snyder
Nov 1, 1979·American Heart Journal·R A Nadeau, J de Champlain
Dec 1, 1979·Circulation Research·B I JugduttL C Becker
Mar 15, 1978·Experientia·M Göthert, J M Rieckesmann
Jul 1, 1978·Critical Care Medicine·H BreivikJ V Snyder
Sep 1, 1978·Anesthesiology·K E Becker, A S Tonnesen
Nov 6, 1975·The New England Journal of Medicine·S F Vatner, E Braunwald
Apr 1, 1973·The American Journal of Cardiology·W E Shell, B E Sobel
Jan 1, 1983·American Heart Journal·F H SheehanS E Epstein

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Citations

Jan 1, 1990·Basic Research in Cardiology·R G SchoemakerJ F Smits
Jul 1, 1987·Progress in Cardiovascular Diseases·L C Becker, G Ambrosio

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