Increased myocardial methionine-enkephalin with reduced arterial oxygenation in congenital heart disease

Journal of Paediatrics and Child Health
Olivier W V van den BrinkSalvatore Pepe

Abstract

Cardiac opioid peptides have been identified to exert important adaptive metabolic signalling for cardioprotection against ischaemia or hypoxia-related injury. To determine myocardial methionine-enkephalin content in children with hypoxemic congenital heart defects and to correlate myocardial content of methionine-enkephalin with the extent of arterial oxygen desaturation. Children (n= 20, median age of 16 months), undergoing cardiac surgical repair (tetralogy of Fallot, 17/20), were included in this study. Arterial oxygen saturation was measured on admission. Myocardial samples obtained during surgery were assayed via radioimmunochemistry for methionine-enkephalin content. Greater methionine-enkephalin content was measured in the right ventricles of the patients suffering from recent cyanotic spells compared with those with no recent spells (cyanotic spells: 2418 ± 844 pg/g wet weight tissue, n= 6; no spells: 1175 ± 189 pg/g wet weight tissue, n= 14, P= 0.04). An inverse correlation was evident between the arterial oxygen saturation and myocardial methionine-enkephalin content. Myocardial methionine-enkephalin levels increase with the severity of hypoxic stress in congenital cardiac disease and may play an important adaptive r...Continue Reading

References

Dec 1, 1979·The Journal of Clinical Endocrinology and Metabolism·S L WardlawA G Frantz
Jan 1, 1991·Biology of the Neonate·A M MartinezS L Thio
Jan 1, 1988·General Pharmacology·A D MosnaimS Diamond
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·J W Holaday
Sep 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D K Rorie, G M Tyce
Jun 1, 1994·Journal of Molecular and Cellular Cardiology·J L CaffreyE G Lakatta
Jun 7, 2000·Neuroreport·X Q Chen, J Z Du
Jan 5, 2002·Autonomic Neuroscience : Basic & Clinical·K E JacksonJ L Caffrey
Aug 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·M FariasJ L Caffrey
Mar 1, 1961·British Heart Journal·A M JOHNSON
Jul 28, 2004·Cardiovascular Research·Salvatore PepeRui-Ping Xiao
Aug 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher E MascioJeffrey L Segar
Sep 16, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Antoine YounèsEdward G Lakatta
Sep 29, 2005·Pediatric Research·J Carter RalpheThomas D Scholz
Dec 15, 2005·Heart, Lung & Circulation·Olivier W V van den BrinkSalvatore Pepe
Aug 16, 2006·Heart·Elliot A ShinebourneJulene S Carvalho
Nov 7, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Santosh B ShindeAnil G Tendolkar
May 1, 2007·The Journal of Thoracic and Cardiovascular Surgery·Wanjun LuoRimao Huang

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Citations

Nov 10, 2015·Peptides·Richard J Bodnar
Feb 19, 2013·The Journal of Thoracic and Cardiovascular Surgery·Bryn O JonesMichael M H Cheung
Apr 29, 2020·Journal of Women's Health·Kara M WhitakerJihong Liu
Jul 31, 2019·Clinical and Experimental Pharmacology & Physiology·Michelle W NgSalvatore Pepe

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