PMID: 591977Oct 1, 1977

Increased myofibrillar protein catabolism in Duchenne muscular dystrophy measured by 3-methylhistidine excretion in the urine

Journal of Neurology, Neurosurgery, and Psychiatry
R O McKeranP Purkiss

Abstract

Myofibrillar protein catabolic rate was calculated in seven patients with Duchenne muscular dystrophy from the amount of 3-methylhistidine excreted in the urine, and found to be over three times that found in a control series when expresses as the percentage of myofibrillar protein catabolised per day. It is suggested that measurement of myofibrillar protein catabolic rate may add a useful parameter in the study of muscle disorders.

Related Concepts

Teens
Histidine
Methylhistidines
Muscle Proteins
Muscular Dystrophy
Myofilaments

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