Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

Journal of Molecular and Cellular Cardiology
Sabine Huke, Björn C Knollmann

Abstract

Increased myofilament Ca(2+) sensitivity is a common attribute of many inherited and acquired cardiomyopathies that are associated with cardiac arrhythmias. Accumulating evidence supports the concept that increased myofilament Ca(2+) sensitivity is an independent risk factor for arrhythmias. This review describes and discusses potential underlying molecular and cellular mechanisms how myofilament Ca(2+) sensitivity affects cardiac excitation and leads to the generation of arrhythmias. Emphasized are downstream effects of increased myofilament Ca(2+) sensitivity: altered Ca(2+) buffering/handling, impaired energy metabolism and increased mechanical stretch, and how they may contribute to arrhythmogenesis.

References

Jun 1, 1977·The Journal of Physiology·G W Beeler, H Reuter
Jan 27, 1992·Annals of the New York Academy of Sciences·C T January, A Moscucci
May 1, 1991·The Journal of Physiology·W H duBellE G Lakatta
Sep 1, 1985·Journal of Molecular and Cellular Cardiology·D G Allen, J C Kentish
Jul 1, 1993·Journal of Molecular and Cellular Cardiology·K A WebsterN H Bishopric
Sep 1, 1993·Japanese Heart Journal·T NambaH Matsubara
Dec 15, 1995·The Journal of Physiology·S Kurihara, K Komukai
Jan 1, 1995·Journal of Cardiovascular Pharmacology·J E Nielsen-Kudsk, J Aldershvile
Mar 1, 1997·Journal of the American College of Cardiology·J C MoolmanH Watkins
Oct 6, 1997·The Journal of Clinical Investigation·K ShivkumarJ N Weiss
Oct 7, 1997·Circulation·G S BodorP A Anderson
May 1, 1998·Biological Chemistry·P ArdeltG Notohamiprodjo
Oct 14, 1998·The Journal of Clinical Investigation·Q YangJ Robbins
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·H L SweeneyH Watkins
Dec 29, 1998·The Journal of Biological Chemistry·S A JohnJ N Weiss
Feb 17, 1999·Journal of Molecular and Cellular Cardiology·D J GrandisA P Koretsky
Mar 17, 1999·Circulation·J M PastoreD S Rosenbaum
Aug 31, 1999·Journal of Cardiovascular Electrophysiology·T J WuP S Chen

❮ Previous
Next ❯

Citations

Feb 22, 2012·Circulation Research·Todd J HerronJosé Jalife
Apr 23, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Weihua SongNancy A Curtin
May 25, 2013·Circulation Research·Sabine Huke, Björn C Knollmann
Jul 12, 2012·Journal of Geriatric Cardiology : JGC·Pierre-Yves Jean-CharlesXu-Pei Huang
Aug 11, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Sophie GüntherJoachim Neumann
May 9, 2015·Journal of Molecular and Cellular Cardiology·Masahito MiuraChiyohiko Shindoh
Mar 23, 2011·Pharmacology & Therapeutics·Jérôme ThireauSylvain Richard
Nov 9, 2010·Journal of Molecular and Cellular Cardiology·Nabeel J Al MoamenGary E Shull
Feb 17, 2015·Journal of Molecular and Cellular Cardiology·Cornelis J WeelandEsther E Creemers
Apr 5, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Peter LeePeter Kohl
Jan 30, 2015·Cardiovascular Research·Jolanda van der VeldenLucie Carrier
Jan 31, 2015·Cardiovascular Research·Jil C TardiffJolanda van der Velden
Jul 15, 2016·Nature Reviews. Cardiology·Julian O M OrmerodMark V Sherrid
Feb 28, 2016·Cardiac Electrophysiology Clinics·Marwan M RefaatGeorges Nemer
Apr 29, 2011·The New England Journal of Medicine·Hugh WatkinsCharles Redwood
Jan 27, 2017·Nucleus·Daniel Brayson, Catherine M Shanahan
Apr 27, 2017·The Journal of Physiology·Kristina LorenzJoachim P Schmitt
Feb 17, 2017·The Journal of Physiology·Sabine Huke
Feb 10, 2017·The Journal of Physiology·Jennifer E Gilda, Aldrin V Gomes
Jun 27, 2017·Progress in Biophysics and Molecular Biology·Melanie A Zile, Natalia A Trayanova
May 15, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Y ChengJ E Stelzer
Sep 10, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Christina T RowlandsKenneth T MacLeod
Aug 22, 2017·Frontiers in Physiology·Sabrina StückerFelix W Friedrich
Aug 28, 2018·Frontiers in Physiology·Michelle M MonaskyLuigi Anastasia
Sep 10, 2020·Frontiers in Bioengineering and Biotechnology·Iris RibitschLouis C Penning
Nov 15, 2016·Frontiers in Physiology·Jessica KrakerSakthivel Sadayappan
Sep 1, 2017·Heart Failure Reviews·Daniel J PhilipsonArnold S Baas
Dec 23, 2016·Clinical Medicine Insights. Cardiology·Peter Baumeister, T Alexander Quinn
Nov 1, 2016·Pflügers Archiv : European journal of physiology·Zai Hao ZhaoYin Hua Zhang
Jun 23, 2019·Journal of Muscle Research and Cell Motility·Steven Marston
Jan 6, 2021·Pflügers Archiv : European journal of physiology·Satadru K LahiriXander H T Wehrens
Jun 13, 2020·Journal of Molecular and Cellular Cardiology·Jamie R BhagwanChris Denning
May 7, 2021·Journal of Molecular and Cellular Cardiology·Frederik FlennerLucie Carrier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.