PMID: 9436620Jan 22, 1998Paper

Increased NADH oxidase activity in the retina of the BBZ/Wor diabetic rat

Free Radical Biology & Medicine
E A EllisG A Lutty

Abstract

This morphological study demonstrates a role for endothelial cells in generating reactive oxygen species in early stages of retinopathy in the BBZ/Wor rat, an obese, noninsulin dependent model of diabetes. Hyperglycemia induced pseudohypoxia results in an imbalance in cytosolic NADH/NAD+. In the oxygen-rich environment of the retina, NADH oxidase generates superoxide radical which is dismutated to hydrogen peroxide. Localization of hydrogen peroxide by the cerium NADH oxidase enzyme activity cytochemical localization technique shows a statistically significant increase of peroxide localization in the central retina of diabetic rats as compared to age-matched, nondiabetic controls. Endothelial cell dysfunction, indicated by leakage of endogenous serum albumin, coincided with areas of NADH oxidase activity localization. In diabetic rats there are increased levels of fibronectin in areas of hydrogen peroxide localization. This in vivo, morphological study is the first demonstration of oxidative injury and endothelial cell dysfunction in the retina of a spontaneous, noninsulin dependent model of diabetes.

References

Jul 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·A CerielloP J Lefèbvre
Feb 1, 1992·Archives of Ophthalmology·G A Lutty, D S McLeod
Jan 1, 1991·Free Radical Biology & Medicine·D Armstrong, F al-Awadi
Mar 1, 1991·Diabetes/metabolism Reviews·G PuglieseJ R Williamson
Nov 1, 1990·Archives of Ophthalmology·J GuyN A Rao
Jan 1, 1990·Journal of Molecular and Cellular Cardiology·M ShlaferC M Grum
Jun 1, 1990·The Journal of Clinical Investigation·J J LynchA B Malik
Jan 1, 1988·Free Radical Biology & Medicine·L W Oberley
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Rosen, B A Freeman
Sep 1, 1981·The Journal of Clinical Investigation·S J WeissN F Nimeh
Nov 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Bendayan
Mar 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H ZhangC D Agardh
Mar 1, 1994·Free Radical Biology & Medicine·B Tesfamariam
Oct 1, 1993·Diabetologia·D L GuberskiA A Like
Jul 8, 1999·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·R AvenaM Bukowski

❮ Previous
Next ❯

Citations

Sep 8, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sul Gee LeeHyun Woong Kim
Oct 9, 2003·The Journal of Laboratory and Clinical Medicine·Yakup AliciguzelUmit Karayalcin
Feb 27, 2001·Neurochemistry International·R A KowluruT S Kern
Apr 16, 2002·Current Opinion in Pharmacology·Christine G Schnackenberg
Jul 31, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Qiuhong LiWilliam W Hauswirth
Jul 9, 2002·Diabetes, Obesity & Metabolism·U Bayraktutan
Nov 26, 2009·The Journal of Experimental Medicine·Julia V BusikMaria B Grant
Dec 17, 2005·Antioxidants & Redox Signaling·E Ann EllisMaria B Grant
Dec 17, 2005·Antioxidants & Redox Signaling·Martin J Stevens
Dec 17, 2005·Antioxidants & Redox Signaling·Carl-David AgardhElisabet Agardh
Jan 15, 2005·Antioxidants & Redox Signaling·Giovanni DavìCarlo Patrono
Mar 25, 2009·Antioxidants & Redox Signaling·Masuko Ushio-Fukai, Norifumi Urao
Feb 19, 2005·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Barbara A DeneJohn B Watkins
Jan 31, 2009·Cardiovascular Research·Ling Gao, Giovanni E Mann
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Nozomu MatsunagaHideaki Hara
Jul 2, 2004·ILAR Journal·Rebecca S TirabassiDennis L Guberski
Dec 17, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Arthur Stevens
Aug 10, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Julie NijmehElizabeth M Wagner
Apr 4, 2001·The Journal of Clinical Investigation·V M Monnier
Oct 31, 2012·Journal of Leukocyte Biology·Ramaprasad TalahalliRose A Gubitosi-Klug
Aug 2, 2005·Treatments in Endocrinology·Ricardo P GarayCarlo Chiavaroli
Oct 23, 2002·Acta Ophthalmologica Scandinavica·Thomas A CiullaBruce Martin
Oct 31, 2015·Microscopy Research and Technique·E Ann Ellis
Oct 14, 2004·Diabetes, Obesity & Metabolism·P WeidigU Bayraktutan
Nov 26, 2010·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Vickie H Y WongAlgis J Vingrys
Oct 13, 2009·Fundamental & Clinical Pharmacology·Ulrike Muscha SteckelingsThomas Unger
Jul 14, 2004·European Journal of Pharmacology·Rossella RotaPatrick Hannaert
Nov 6, 2003·Redox Report : Communications in Free Radical Research·David M van ReykMichael J Davies
Dec 24, 2013·Oxidative Medicine and Cellular Longevity·Akshay AnandRamandeep Singh
Oct 8, 2004·Journal of Biochemistry and Molecular Biology·Se-Jin ChungYoung-Hee Kang
Mar 15, 2013·Clinical Science·Alan W StittTimothy M Curtis
Jan 5, 2001·Expert Opinion on Investigational Drugs·P J Oates, B L Mylari
Jul 26, 2008·Progress in Retinal and Eye Research·J S PennM E Hartnett

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.